Literature DB >> 25019214

MKK6 is upregulated in human esophageal, stomach, and colon cancers.

Arif Ali Parray1, Rafia Anjum Baba, Hina Fayaz Bhat, Lateef Wani, Taseem Ahmad Mokhdomi, Umar Mushtaq, Sehar Saleem Bhat, Deeba Kirmani, Sanaullah Kuchay, Mudassir Maqbool Wani, Firdous Ahmad Khanday.   

Abstract

Expression analysis of MKK6 protein in solid tumors has never been investigated. Here, we report systematic analysis of MKK6 protein in different types of human tumor samples using western blotting and immunofluorescence techniques. We observed significant increase in the expression of MKK6 in Esophageal, Stomach, and Colon cancers as compared to controls. Results were alternately confirmed by Immunofluorescence studies. Upregulation of MKK6 protein is indicative of its role in human cancers and could possibly be used as a novel diagnostic or prognostic marker in these cancers.

Entities:  

Keywords:  Cancers; MKK6; Protein expression

Mesh：

Substances：

Year:  2014        PMID： 25019214     DOI： 10.3109/07357907.2014.933236

Source DB:  PubMed          Journal:  Cancer Invest        ISSN： 0735-7907            Impact factor:   2.176


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  9 in total

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