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Literature DB >> 25019071

OPN sesame.

Abstract

Osteopontin (OPN) is a growth regulatory protein for hepatocellular carcinoma (HCC) and a potent chemoattractant for macrophages. Zhu and colleagues recently reported significant clinical associations between poor postoperative prognosis and the concurrent detection of tumoral OPN expression and peritumoral macrophage (PTM) infiltration. An in-depth understanding on the complex interaction between tumoral OPN and macrophage-infiltrated microenvironment opens new doors to novel anticancer treatments.

Entities: Disease Species

Keywords: Metastasis; cancer recurrence; early detection; inflammation

Year: 2014 PMID： 25019071 PMCID： PMC4073313 DOI： 10.3978/j.issn.2304-3881.2014.02.09

Source DB: PubMed Journal: Hepatobiliary Surg Nutr ISSN： 2304-3881 Impact factor: 7.293

15 in total

Review 1. Immunity, inflammation, and cancer.

Authors: Sergei I Grivennikov; Florian R Greten; Michael Karin
Journal: Cell Date: 2010-03-19 Impact factor: 41.582

2. A constitutive endogenous osteopontin production is important for macrophage function and differentiation.

Authors: Tobias Nyström; Ponuts Dunér; Anna Hultgårdh-Nilsson
Journal: Exp Cell Res Date: 2007-01-12 Impact factor: 3.905

3. The prognostic significance of preoperative plasma levels of osteopontin in patients with hepatocellular carcinoma.

Authors: Hui Zhang; Qing-Hai Ye; Ning Ren; Lei Zhao; Yan-Fang Wang; Xin Wu; Hui-Chuan Sun; Lu Wang; Bo-Heng Zhang; Yin-Kun Liu; Zhao-You Tang; Lun-Xiu Qin
Journal: J Cancer Res Clin Oncol Date: 2006-06-20 Impact factor: 4.553

4. Osteopontin, a single marker for predicting the prognosis of patients with tumor-node-metastasis stage I hepatocellular carcinoma after surgical resection.

Authors: Rong-Xin Chen; Yun-Hong Xia; Jie-Feng Cui; Tong-Chun Xue; Sheng-Long Ye
Journal: J Gastroenterol Hepatol Date: 2010-08 Impact factor: 4.029

Review 5. Osteopontin, intrinsic tissue regulator of intractable inflammatory diseases.

Authors: Toshimitsu Uede
Journal: Pathol Int Date: 2011-03-08 Impact factor: 2.534

6. The prognostic significance of preoperative plasma levels of osteopontin in patients with TNM stage-I of hepatocellular carcinoma.

Authors: Jian Sun; Hong-Mei Xu; Hai-Jun Zhou; Qiong-Zhu Dong; Yue Zhao; Li-Yun Fu; Zhen-Yu Hei; Qing-Hai Ye; Ning Ren; Hu-Liang Jia; Lun-Xiu Qin
Journal: J Cancer Res Clin Oncol Date: 2010-01 Impact factor: 4.553

7. High tumor-infiltrating macrophage density predicts poor prognosis in patients with primary hepatocellular carcinoma after resection.

Authors: Tong Ding; Jing Xu; Fang Wang; Ming Shi; Ying Zhang; Sheng-Ping Li; Limin Zheng
Journal: Hum Pathol Date: 2008-11-07 Impact factor: 3.466

OPN sesame.

Review 1. Immunity, inflammation, and cancer.

2. A constitutive endogenous osteopontin production is important for macrophage function and differentiation.

3. The prognostic significance of preoperative plasma levels of osteopontin in patients with hepatocellular carcinoma.

4. Osteopontin, a single marker for predicting the prognosis of patients with tumor-node-metastasis stage I hepatocellular carcinoma after surgical resection.

Review 5. Osteopontin, intrinsic tissue regulator of intractable inflammatory diseases.

6. The prognostic significance of preoperative plasma levels of osteopontin in patients with TNM stage-I of hepatocellular carcinoma.

7. High tumor-infiltrating macrophage density predicts poor prognosis in patients with primary hepatocellular carcinoma after resection.

8. A humanized anti-osteopontin antibody inhibits breast cancer growth and metastasis in vivo.

Review 9. Hallmarks of cancer: the next generation.

10. Management of hepatocellular carcinoma: an update.

Review 1. The Role of Osteopontin in Tumor Progression Through Tumor-Associated Macrophages.