Literature DB >> 25018023

Human herpesvirus 8 glycoprotein B binds the entry receptor DC-SIGN.

Heather R Hensler1, Monica J Tomaszewski1, Giovanna Rappocciolo1, Charles R Rinaldo2, Frank J Jenkins3.   

Abstract

We have previously shown that human herpesvirus 8 (HHV-8) uses DC-SIGN as an entry receptor for dendritic cells, macrophages and B cells. The viral attachment protein for DC-SIGN is unknown. HHV-8 virions contain five conserved herpesvirus glycoproteins, a single unique glycoprotein, and two predicted glycoproteins. Previous studies have shown that DC-SIGN binds highly mannosylated glycoproteins. The HHV-8 glycoprotein B (gB) has been reported to be highly mannosylated, and therefore we hypothesized that gB will bind to DC-SIGN. In this report we confirm that gB has a high mannose carbohydrate structure and demonstrate for the first time that it binds DC-SIGN in a dose-dependent manner. We also identify key amino acids in the DC-SIGN carbohydrate recognition domain that are required for HHV-8 infection and compare these results with published binding regions for ICAM-2/3 and HIV-1 gp120. These results clarify some of the initial events in HHV-8 entry and can be used for the design of targeted preventive therapies.
Copyright © 2014 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  DC-SIGN; Human herpesvirus 8

Mesh：

Substances：

Year:  2014        PMID： 25018023      PMCID： PMC4142096          DOI： 10.1016/j.virusres.2014.07.003

Source DB:  PubMed          Journal:  Virus Res        ISSN： 0168-1702            Impact factor:   3.303


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