Metal-free oxidative direct C(sp³)-H bond functionalization of ethers with α,α-diaryl allylic alcohols.

A metal-free method for direct C(sp(3))-H bond functionalization of simple ethers with α,α-diaryl allylic alcohols is described. The established protocol provides facile access to α-aryl-β-oxyalkylated carbonyl ketones via radical addition and a 1,2-aryl migration cascade process. An application of the product has been demonstrated in the synthesis of a serotonin antagonist.