Yoko Matsuzaki1, Kanetsu Sugawara2, Chieko Abiko3, Tatsuya Ikeda3, Yoko Aoki3, Katsumi Mizuta3, Noriko Katsushima4, Fumio Katsushima4, Yuriko Katsushima4, Tsutomu Itagaki5, Yoshitaka Shimotai2, Seiji Hongo2, Yasushi Muraki6, Hidekazu Nishimura7. 1. Department of Infectious Diseases, Yamagata University Faculty of Medicine, Iida-Nishi, Yamagata 990-9585, Japan. Electronic address: matuzaki@med.id.yamagata-u.ac.jp. 2. Department of Infectious Diseases, Yamagata University Faculty of Medicine, Iida-Nishi, Yamagata 990-9585, Japan. 3. Department of Microbiology, Yamagata Prefectural Institute of Public Health, Tokamachi, Yamagata 990-0031, Japan. 4. Katsushima Pediatric Clinic, Minamidate, Yamagata 990-2461, Japan. 5. Yamanobe Pediatric Clinic, Yamanobe, Yamagata 990-0301, Japan. 6. Department of Infectious Diseases, Yamagata University Faculty of Medicine, Iida-Nishi, Yamagata 990-9585, Japan; Department of Microbiology, Kanazawa Medical University School of Medicine, Uchinada, Ishikawa 920-0293, Japan. 7. Virus Research Center, Clinical Research Division, Sendai Medical Center, Miyagino-ku, Sendai, Miyagi 983-8520, Japan.
Abstract
BACKGROUND: Although influenza C virus is widely distributed throughout the world, epidemiological information, based on long-term surveillance, has not yet been acquired. OBJECTIVES: To clarify the epidemiological features of influenza C virus infection, and to examine whether the prevalence of the antibodies against the influenza C virus is associated with the epidemics. STUDY DESIGN: Between 1996 and 2013, 36,973 respiratory specimens were collected from two pediatric outpatient clinics in Yamagata, Japan. The specimens were examined for the presence of influenza C virus using cell culture methods. Isolated viruses were antigenically analyzed. The differences in seropositivity, with respect to the different antigenic groups, were examined using serum samples collected in 2001 and 2011 by a hemagglutination inhibition assay. RESULTS: Influenza C viruses were isolated from 190 specimens during an 18-year period. Most influenza C viruses were isolated from winter to early summer in even-numbered years, and the frequency of virus isolation per year ranged from 0.43% to 1.73%. An antigenic analysis revealed that the dominant antigenic groups were the C/Yamagata/26/81 from 1996 to 2000, the C/Kanagawa/1/76 in 2002 and 2004, and the C/Sao Paulo/378/82 from 2006 to 2012. When compared to the other antigenic groups, the seroprevalence of the C/Sao Paulo/378/82 group was lower in 2001 for individuals older than 5 years and was higher in 2011 in individuals younger than 40 years. CONCLUSIONS: The results from our study suggest that epidemics of influenza C virus infection periodically occur and the replacement of the dominant antigenic group may be caused by immune selection within older children and/or adults in the community.
BACKGROUND: Although influenza C virus is widely distributed throughout the world, epidemiological information, based on long-term surveillance, has not yet been acquired. OBJECTIVES: To clarify the epidemiological features of influenza C virus infection, and to examine whether the prevalence of the antibodies against the influenza C virus is associated with the epidemics. STUDY DESIGN: Between 1996 and 2013, 36,973 respiratory specimens were collected from two pediatric outpatient clinics in Yamagata, Japan. The specimens were examined for the presence of influenza C virus using cell culture methods. Isolated viruses were antigenically analyzed. The differences in seropositivity, with respect to the different antigenic groups, were examined using serum samples collected in 2001 and 2011 by a hemagglutination inhibition assay. RESULTS:Influenza C viruses were isolated from 190 specimens during an 18-year period. Most influenza C viruses were isolated from winter to early summer in even-numbered years, and the frequency of virus isolation per year ranged from 0.43% to 1.73%. An antigenic analysis revealed that the dominant antigenic groups were the C/Yamagata/26/81 from 1996 to 2000, the C/Kanagawa/1/76 in 2002 and 2004, and the C/Sao Paulo/378/82 from 2006 to 2012. When compared to the other antigenic groups, the seroprevalence of the C/Sao Paulo/378/82 group was lower in 2001 for individuals older than 5 years and was higher in 2011 in individuals younger than 40 years. CONCLUSIONS: The results from our study suggest that epidemics of influenza C virus infection periodically occur and the replacement of the dominant antigenic group may be caused by immune selection within older children and/or adults in the community.
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