Literature DB >> 25017034

Confronting the challenges of discovery of novel antibacterial agents.

Sheo B Singh1.   

Abstract

Bacterial resistance is inevitable and is a growing concern. It can be addressed only by discovery and development of new agents. However the discovery and development of new antibacterial agents are at an all time low. This article broadly examines the historical as well as current status of antibacterial discovery and provides some perspective as how to address some of the challenges.
Copyright © 2014 The Author. Published by Elsevier Ltd.. All rights reserved.

Keywords:  Antibacterial; Antimicrobial; Discovery strategy; Phenotypic screening; Topoisomerase II

Mesh：

Substances：

Year:  2014        PMID： 25017034     DOI： 10.1016/j.bmcl.2014.06.053

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  20 in total

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Authors:  Mark S Butler; Mark At Blaskovich; Matthew A Cooper
Journal:  J Antibiot (Tokyo)       Date:  2016-06-29       Impact factor: 2.649

2.  Recent Advances in the Rational Design and Optimization of Antibacterial Agents.

Authors:  Jesse A Jones; Kristopher G Virga; Giuseppe Gumina; Kirk E Hevener
Journal:  Medchemcomm       Date:  2016-07-07       Impact factor: 3.597

3.  Endless Resistance. Endless Antibiotics?

Authors:  Jed F Fisher; Shahriar Mobashery
Journal:  Medchemcomm       Date:  2015-11-03       Impact factor: 3.597

4.  Rational design, synthesis and testing of novel tricyclic topoisomerase inhibitors for the treatment of bacterial infections part 1.

Authors:  R Kirk; A Ratcliffe; G Noonan; M Uosis-Martin; D Lyth; O Bardell-Cox; J Massam; P Schofield; S Hindley; D R Jones; J Maclean; A Smith; V Savage; S Mohmed; C Charrier; A-M Salisbury; E Moyo; R Metzger; N Chalam-Judge; J Cheung; N R Stokes; S Best; M Craighead; R Armer; A Huxley
Journal:  RSC Med Chem       Date:  2020-09-18

5.  Click Chemistry in Lead Optimization of Boronic Acids as β-Lactamase Inhibitors.

Authors:  Emilia Caselli; Chiara Romagnoli; Roza Vahabi; Magdalena A Taracila; Robert A Bonomo; Fabio Prati
Journal:  J Med Chem       Date:  2015-07-10       Impact factor: 7.446

6.  Identification of novel targets of azithromycin activity against Pseudomonas aeruginosa grown in physiologically relevant media.

Authors:  Corrie R Belanger; Amy Huei-Yi Lee; Daniel Pletzer; Bhavjinder Kaur Dhillon; Reza Falsafi; Robert E W Hancock
Journal:  Proc Natl Acad Sci U S A       Date:  2020-12-14       Impact factor: 11.205

7.  Pharmacodynamic Profile of GSK2140944 against Methicillin-Resistant Staphylococcus aureus in a Murine Lung Infection Model.

Authors:  Wonhee So; Jared L Crandon; David P Nicolau
Journal:  Antimicrob Agents Chemother       Date:  2015-06-08       Impact factor: 5.191

8.  Novel Bacterial Topoisomerase Inhibitors with Potent Broad-Spectrum Activity against Drug-Resistant Bacteria.

Authors:  Cédric Charrier; Anne-Marie Salisbury; Victoria J Savage; Thomas Duffy; Emmanuel Moyo; Nathan Chaffer-Malam; Nicola Ooi; Rebecca Newman; Jonathan Cheung; Richard Metzger; David McGarry; Mark Pichowicz; Ralph Sigerson; Ian R Cooper; Gary Nelson; Hayley S Butler; Mark Craighead; Andrew J Ratcliffe; Stuart A Best; Neil R Stokes
Journal:  Antimicrob Agents Chemother       Date:  2017-04-24       Impact factor: 5.191

Review 9.  Drug repurposing for antimicrobial discovery.

Authors:  Maya A Farha; Eric D Brown
Journal:  Nat Microbiol       Date:  2019-03-04       Impact factor: 17.745

10.  Statistical research on the bioactivity of new marine natural products discovered during the 28 years from 1985 to 2012.

Authors:  Yiwen Hu; Jiahui Chen; Guping Hu; Jianchen Yu; Xun Zhu; Yongcheng Lin; Shengping Chen; Jie Yuan
Journal:  Mar Drugs       Date:  2015-01-07       Impact factor: 5.118
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