Literature DB >> 2501671

Activity of pp60c-src protein kinase in human breast cancer.

S Lehrer, J O'Shaughnessy, H K Song, E Levine, P Savoretti, J Dalton, R Lipsztein, S Kalnicki, W D Bloomer.   

Abstract

Because there is elevation of pp60c-src activity in breast carcinoma tissue, we analyzed primary breast cancer tissue samples from 30 women to determine whether pp60c-src activity correlated with specific clinical parameters. We found that tumors with a progesterone receptor had higher pp60c-src activity than tumors without such a receptor. But there was no association of pp60c-src activity with the presence of an estrogen receptor or of nodes, or with menopausal status or age. The function of pp60c-src in normal cells and in breast cancer is unknown, as is the significance of our finding of an association of elevated pp60c-src activity and the presence of progesterone receptors.

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Year:  1989        PMID： 2501671

Source DB:  PubMed          Journal:  Mt Sinai J Med        ISSN： 0027-2507


  5 in total

1.  Progesterone receptors upregulate Wnt-1 to induce epidermal growth factor receptor transactivation and c-Src-dependent sustained activation of Erk1/2 mitogen-activated protein kinase in breast cancer cells.

Authors:  Emily J Faivre; Carol A Lange
Journal:  Mol Cell Biol       Date:  2006-10-30       Impact factor: 4.272

Review 2.  Oestrogen and growth factor cross-talk and endocrine insensitivity and acquired resistance in breast cancer.

Authors:  R I Nicholson; J M Gee
Journal:  Br J Cancer       Date:  2000-02       Impact factor: 7.640

3.  Csk-homologous kinase (Chk) is an efficient inhibitor of Src-family kinases but a poor catalyst of phosphorylation of their C-terminal regulatory tyrosine.

Authors:  Gahana Advani; Ya Chee Lim; Bruno Catimel; Daisy Sio Seng Lio; Nadia L Y Ng; Anderly C Chüeh; Mai Tran; Mohd Ishtiaq Anasir; Heather Verkade; Hong-Jian Zhu; Benjamin E Turk; Thomas E Smithgall; Ching-Seng Ang; Michael Griffin; Heung-Chin Cheng
Journal:  Cell Commun Signal       Date:  2017-08-07       Impact factor: 5.712

4.  The Study of Microbe-Host Two-Way Communication.

Authors:  Famatta Perry; Ryan J Arsenault
Journal:  Microorganisms       Date:  2022-02-10

5.  Age-specific differences in oncogenic pathway deregulation seen in human breast tumors.

Authors:  Carey K Anders; Chaitanya R Acharya; David S Hsu; Gloria Broadwater; Katherine Garman; John A Foekens; Yi Zhang; Yixin Wang; Kelly Marcom; Jeffrey R Marks; Sayan Mukherjee; Joseph R Nevins; Kimberly L Blackwell; Anil Potti
Journal:  PLoS One       Date:  2008-01-02       Impact factor: 3.240
  5 in total

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