Francesca Mattei1, Florence Guida1, Mireille Matrat2, Sylvie Cenée1, Diane Cyr3, Marie Sanchez1, Loredana Radoi4, Gwenn Menvielle5, Fatima Jellouli6, Matthieu Carton3, Simona Bara7, Emilie Marrer8, Danièle Luce9, Isabelle Stücker1. 1. INSERM, UMRS 1018, CESP Centre for Research in Epidemiology and Population Health, Environmental Epidemiology of Cancer, Villejuif, France University of Paris Sud 11, UMRS 1018, Villejuif, France. 2. INSERM, U955, Créteil Cedex, France Centre Hospitalier Intercommunal, Créteil Cedex, France. 3. INSERM, Epidemiologic Cohorts Unit-UMS 011 INSERM-UVSQ, Villejuif, France University of Versailles St-Quentin, UMS 011, Villejuif, France. 4. INSERM, UMRS 1018, CESP Centre for Research in Epidemiology and Population Health, Epidemiology of Occupational and Social Determinants of Health, Villejuif, France Faculty of Dental Surgery, University Paris Descartes, Paris, France. 5. INSERM, UMR_S 1136, Pierre Louis Institute of Epidemiology and Public Health, Villejuif, France Sorbonne University, UPMC University of Paris 06, UMR_S 1136, Pierre Louis Institute of Epidemiology and Public Health, Villejuif, France. 6. INSERM, UMRS 1018, CESP Centre for Research in Epidemiology and Population Health, Epidemiology of Occupational and Social Determinants of Health, Villejuif, France University of Versailles St-Quentin, UMRS 1018, Villejuif, France. 7. Registre des Cancers de la Manche, Cherbourg-Octeville, France. 8. Registre des Cancers du Haut-Rhin, Mulhouse, France. 9. INSERM, U 1085_IRSET, Campus de Fouillole-BP 145, Pointe-à-Pitre, Guadeloupe, French West Indies University of Rennes 1, Campus de Fouillole-BP 145, Pointe-à-Pitre, Guadeloupe, French West Indies.
Abstract
OBJECTIVE: To investigate the role of occupational exposure to chlorinated solvents in lung cancer aetiology. METHODS: ICARE (Investigation of occupational and environmental CAuses of REspiratory cancers) is a French, multicentre, population-based, case-control study. Information on the lifelong work history of 2926 cases and 3555 controls was collected using standardised questionnaires. Occupational exposures were assessed using job-exposure matrices for five chlorinated solvents. Solvents were studied separately and in combinations. ORs were computed using unconditional logistic regression models adjusted for classic risk factors, including a history of cigarette smoking and exposure to asbestos. Adjustment for socioeconomic status (SES) was also made. RESULTS: After adjustment for exposure to asbestos, we observed a positive, statistically significant association with lung cancer for men and women exposed to a combination of perchloroethylene (PCE), trichloroethylene and dichloromethane (DCM). Further adjustment for SES slightly decreased this association. In contrast, no statistically significant associations were found for other solvent combinations. CONCLUSIONS: These results suggest that exposure to PCE may constitute a risk factor for lung cancer, especially among women, who seem to have a higher prevalence of exposure than men. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.
OBJECTIVE: To investigate the role of occupational exposure to chlorinated solvents in lung cancer aetiology. METHODS: ICARE (Investigation of occupational and environmental CAuses of REspiratory cancers) is a French, multicentre, population-based, case-control study. Information on the lifelong work history of 2926 cases and 3555 controls was collected using standardised questionnaires. Occupational exposures were assessed using job-exposure matrices for five chlorinated solvents. Solvents were studied separately and in combinations. ORs were computed using unconditional logistic regression models adjusted for classic risk factors, including a history of cigarette smoking and exposure to asbestos. Adjustment for socioeconomic status (SES) was also made. RESULTS: After adjustment for exposure to asbestos, we observed a positive, statistically significant association with lung cancer for men and women exposed to a combination of perchloroethylene (PCE), trichloroethylene and dichloromethane (DCM). Further adjustment for SES slightly decreased this association. In contrast, no statistically significant associations were found for other solvent combinations. CONCLUSIONS: These results suggest that exposure to PCE may constitute a risk factor for lung cancer, especially among women, who seem to have a higher prevalence of exposure than men. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.