Literature DB >> 2501586

Excretion of hippuric acid during sodium benzoate therapy in patients with hyperglycinaemia or hyperammonaemia.

B A Barshop1, J Breuer, J Holm, J Leslie, W L Nyhan.   

Abstract

In patients with non-ketotic hyperglycinaemia and two patients with urea cycle disorders treated with varying doses of sodium benzoate there was linear correlation between intake of benzoate and excretion of hippurate. Patients with non-ketotic hyperglycinaemia excreted significantly more benzoate in the form of hippurate than patients with urea cycle disorders (74 +/- 7.0 vs 41 +/- 3.6%). The plasma concentration of glycine decreased following benzoate treatment only in the patients with non-ketotic hyperglycinaemia. The observed difference between the two groups in the excretion of hippurate seems to support the concept that glycine availability may be limiting in benzoate therapy for some patients.

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Year:  1989        PMID： 2501586     DOI： 10.1007/bf01805533

Source DB:  PubMed          Journal:  J Inherit Metab Dis        ISSN： 0141-8955            Impact factor:   4.982


  20 in total

1.  The clinical findings in a patient with nonketotic hyperglycinemia.

Authors:  F A Ziter; P F Bray; J A Madsen; W L Nyhan
Journal:  Pediatr Res       Date:  1968-07       Impact factor: 3.756

2.  Treatment of hyperargininemia with sodium benzoate and arginine-restricted diet.

Authors:  I A Qureshi; J Letarte; R Ouellet; M L Batshaw; S Brusilow
Journal:  J Pediatr       Date:  1984-03       Impact factor: 4.406

3.  Evidence of lack of toxicity of sodium phenylacetate and sodium benzoate in treating urea cycle enzymopathies.

Authors:  M L Batshaw; S W Brusilow
Journal:  J Inherit Metab Dis       Date:  1981       Impact factor: 4.982

4.  Chronic benzoate therapy in a boy with partial ornithine transcarbamylase deficiency.

Authors:  J Letarte; I A Qureshi; R Ouellet; M Godard
Journal:  J Pediatr       Date:  1985-05       Impact factor: 4.406

5.  Sodium benzoate and arginine: alternative pathway therapy in inborn errors of urea synthesis.

Authors:  M L Batshaw
Journal:  Prog Clin Biol Res       Date:  1983

6.  Benzoylalanine: detection and identification of an alanine conjugate with benzoic acid in hyperammonemic patients treated with sodium benzoate.

Authors:  T Shinka; Y Inoue; T Kuhara; M Matsumoto; I Matsumoto
Journal:  Clin Chim Acta       Date:  1985-10-15       Impact factor: 3.786

7.  Treatment of episodic hyperammonemia in children with inborn errors of urea synthesis.

Authors:  S W Brusilow; M Danney; L J Waber; M Batshaw; B Burton; L Levitsky; K Roth; C McKeethren; J Ward
Journal:  N Engl J Med       Date:  1984-06-21       Impact factor: 91.245

8.  Activity of the glycine cleavage system in hyperammonemia treated with benzoate.

Authors:  H Kodama; K Fujiwara; Y Motokawa; H Tajiri; O Nose; S Kamoshita
Journal:  Tohoku J Exp Med       Date:  1983-07       Impact factor: 1.848

9.  The effectiveness of benzoate in the management of seizures in nonketotic hyperglycinemia.

Authors:  J A Wolff; S Kulovich; A L Yu; C N Qiao; W L Nyhan
Journal:  Am J Dis Child       Date:  1986-06

10.  Treatment of congenital hyperammonemias.

Authors:  C Bachmann
Journal:  Enzyme       Date:  1984
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  5 in total

1.  Benzoate treatment and the glycine index in nonketotic hyperglycinaemia.

Authors:  J L K Van Hove; K Vande Kerckhove; J B Hennermann; V Mahieu; P Declercq; S Mertens; M De Becker; P S Kishnani; J Jaeken
Journal:  J Inherit Metab Dis       Date:  2005       Impact factor: 4.982

2.  Effect of sodium benzoate in the treatment of atypical nonketotic hyperglycinaemia.

Authors:  J M Neuberger; S Schweitzer; M O Rolland; R Burghard
Journal:  J Inherit Metab Dis       Date:  2000-02       Impact factor: 4.982

Review 3.  Molecular Probes, Chemosensors, and Nanosensors for Optical Detection of Biorelevant Molecules and Ions in Aqueous Media and Biofluids.

Authors:  Joana Krämer; Rui Kang; Laura M Grimm; Luisa De Cola; Pierre Picchetti; Frank Biedermann
Journal:  Chem Rev       Date:  2022-01-07       Impact factor: 60.622

Review 4.  Alternative pathway therapy for urea cycle disorders.

Authors:  F Feillet; J V Leonard
Journal:  J Inherit Metab Dis       Date:  1998       Impact factor: 4.982

Review 5.  The Pharmabiotic Approach to Treat Hyperammonemia.

Authors:  Jing Liu; Enkhchimeg Lkhagva; Hea-Jong Chung; Hyeon-Jin Kim; Seong-Tshool Hong
Journal:  Nutrients       Date:  2018-01-28       Impact factor: 5.717
  5 in total

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