INTRODUCTION: The Clinical Dementia Rating Scale (CDR) is a tool designed to quantify the severity of dementia symptoms and is also useful to assess disease progression, in Alzheimer's disease (AD). A new version of the scale was developed by adding two extra domains that focused on the core aspects of frontotemporal dementia symptomatology, Language and Behavior/Comportment/Personality. OBJECTIVES: In this study, we adapted and validated the modified CDR scale in our setting and language (Rioplatense-Spanish). MATERIALS AND METHODS: 46 patients with probable AD, 27 behavioral variant of Frontotemporal Dementia (bvFTD), 18 Primary Progressive Aphasia (PPA) and 40 healthy participants were included. The adapted version of the scale was administered by a blind rater who interviewed patients together with patient's caregiver. RESULTS: Using ROC curves, the domain language and behavior were superior to the memory domain in accuracy for detecting PPA and bvFTD, respectively, but both of them had equivalent diagnostic accuracies for probable AD. Logistic regression analyses showed that either the LANG or BEHAV domains significantly improved the discrimination between probable AD, bvFTD and PPA. CONCLUSIONS: The Spanish version of the modified CDR adds value for the characterization of the non-amnestic symptoms in patients with neurodegenerative dementias.
INTRODUCTION: The Clinical Dementia Rating Scale (CDR) is a tool designed to quantify the severity of dementia symptoms and is also useful to assess disease progression, in Alzheimer's disease (AD). A new version of the scale was developed by adding two extra domains that focused on the core aspects of frontotemporal dementia symptomatology, Language and Behavior/Comportment/Personality. OBJECTIVES: In this study, we adapted and validated the modified CDR scale in our setting and language (Rioplatense-Spanish). MATERIALS AND METHODS: 46 patients with probable AD, 27 behavioral variant of Frontotemporal Dementia (bvFTD), 18 Primary Progressive Aphasia (PPA) and 40 healthy participants were included. The adapted version of the scale was administered by a blind rater who interviewed patients together with patient's caregiver. RESULTS: Using ROC curves, the domain language and behavior were superior to the memory domain in accuracy for detecting PPA and bvFTD, respectively, but both of them had equivalent diagnostic accuracies for probable AD. Logistic regression analyses showed that either the LANG or BEHAV domains significantly improved the discrimination between probable AD, bvFTD and PPA. CONCLUSIONS: The Spanish version of the modified CDR adds value for the characterization of the non-amnestic symptoms in patients with neurodegenerative dementias.
Authors: Toji Miyagawa; Danielle Brushaber; Jeremy Syrjanen; Walter Kremers; Julie Fields; Leah K Forsberg; Hilary W Heuer; David Knopman; John Kornak; Adam Boxer; Howie Rosen; Bradley Boeve Journal: Alzheimers Dement Date: 2020-01-06 Impact factor: 21.566
Authors: Toji Miyagawa; Danielle Brushaber; Jeremy Syrjanen; Walter Kremers; Julie Fields; Leah K Forsberg; Hilary W Heuer; David Knopman; John Kornak; Adam Boxer; Howard J Rosen; Bradley F Boeve; Brian Appleby; Yvette Bordelon; Jessica Bove; Patrick Brannelly; Christina Caso; Giovanni Coppola; Reilly Dever; Christina Dheel; Bradford Dickerson; Susan Dickinson; Sophia Dominguez; Kimiko Domoto-Reilly; Kelley Faber; Jessica Ferrell; Ann Fishman; Jamie Fong; Tatiana Foroud; Ralitza Gavrilova; Debra Gearhart; Behnaz Ghazanfari; Nupur Ghoshal; Jill S Goldman; Jonathan Graff-Radford; Neill Graff-Radford; Ian Grant; Murray Grossman; Dana Haley; Robin Hsiung; Edward Huey; David Irwin; David Jones; Lynne Jones; Kejal Kantarci; Anna Karydas; Daniel Kaufer; Diana Kerwin; Ruth Kraft; Joel Kramer; Walter Kukull; Irene Litvan; Diane Lucente; Codrin Lungu; Ian Mackenzie; Miranda Maldonado; Masood Manoochehri; Scott McGinnis; Emily McKinley; Mario F Mendez; Bruce Miller; Namita Multani; Chiadi Onyike; Jaya Padmanabhan; Alexander Pantelyat; Rodney Pearlman; Leonard Petrucelli; Madeline Potter; Rosa Rademakers; Eliana M Ramos; Kate Rankin; Katya Rascovsky; Erik D Roberson; Emily Rogalski; Pheth Sengdy; Leslie Shaw; Maria C Tartaglia; Nadine Tatton; Joanne Taylor; Arthur Toga; John Q Trojanowski; Ping Wang; Sandra Weintraub; Bonnie Wong; Zbigniew Wszolek Journal: Alzheimers Dement Date: 2020-01 Impact factor: 21.566
Authors: Fernando Henríquez; Victoria Cabello; Sandra Baez; Leonardo Cruz de Souza; Patricia Lillo; David Martínez-Pernía; Loreto Olavarría; Teresa Torralva; Andrea Slachevsky Journal: Front Neurol Date: 2022-02-16 Impact factor: 4.003