James Olcese1, Stephen Beesley2. 1. Department of Biomedical Sciences, Florida State University College of Medicine, Tallahassee, Florida. Electronic address: James.olcese@med.fsu.edu. 2. Department of Biomedical Sciences, Florida State University College of Medicine, Tallahassee, Florida.
Abstract
OBJECTIVE: To review and update the research on melatonin receptor expression in the human myometrium, in particular as it pertains to uterine contractility at labor. DESIGN: Summary of previous studies with the addition of new data on the transcriptional regulation of melatonin receptor expression in human myometrial cells. SETTING: Not applicable. PATIENT(S): Late-term pregnant volunteers. INTERVENTION(S): Biopsy collection for in vitro analyses provided the original data. More recently, uterine contractions in late-term pregnant volunteers were assessed before, during, and after acute white-light exposure. MAIN OUTCOME MEASURE(S): Melatonin receptor signaling in myometrial cells and uterine contractions in late-term pregnant volunteers. RESULT(S): Melatonin acts through the MTNR1B melatonin receptor that is expressed in the myometrium at late term to synergistically enhance oxytocin-dependent signaling and contractions. Acute inhibition of endogenous melatonin levels with light reversibly suppresses uterine contractions. CONCLUSION(S): These results point to a significant role for circulating melatonin in the timing and degree of uterine contractions in late-term pregnancy. Understanding the regulation of melatonin receptors remains a future objective.
OBJECTIVE: To review and update the research on melatonin receptor expression in the human myometrium, in particular as it pertains to uterine contractility at labor. DESIGN: Summary of previous studies with the addition of new data on the transcriptional regulation of melatonin receptor expression in human myometrial cells. SETTING: Not applicable. PATIENT(S): Late-term pregnant volunteers. INTERVENTION(S): Biopsy collection for in vitro analyses provided the original data. More recently, uterine contractions in late-term pregnant volunteers were assessed before, during, and after acute white-light exposure. MAIN OUTCOME MEASURE(S): Melatonin receptor signaling in myometrial cells and uterine contractions in late-term pregnant volunteers. RESULT(S): Melatonin acts through the MTNR1B melatonin receptor that is expressed in the myometrium at late term to synergistically enhance oxytocin-dependent signaling and contractions. Acute inhibition of endogenous melatonin levels with light reversibly suppresses uterine contractions. CONCLUSION(S): These results point to a significant role for circulating melatonin in the timing and degree of uterine contractions in late-term pregnancy. Understanding the regulation of melatonin receptors remains a future objective.
Authors: Shadab A Rahman; Carolina Bibbo; James Olcese; Charles A Czeisler; Julian N Robinson; Elizabeth B Klerman Journal: J Pineal Res Date: 2019-03-10 Impact factor: 13.007
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