Literature DB >> 2501447

Establishment of human double-positive thymocyte clones.

G De Libero1, A Lanzavecchia.   

Abstract

Human thymocytes were sorted according to the expression of CD4 and CD8 molecules and clones representing the four subpopulations (DP, DN, and single CD4 or CD8 positive) were established. DP clones can be maintained for long periods in tissue culture and give rise to a variable percentage of SP variants. These variants, when isolated and further expanded, do not revert to a DP phenotype. DP clones express a functional TCR-CD3 complex, suggesting that this molecule can interact with the thymic microenvironment during T cell differentiation.

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Year:  1989        PMID： 2501447      PMCID： PMC2189367          DOI： 10.1084/jem.170.1.303

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  13 in total

1.  Antibodies to CD3/T-cell receptor complex induce death by apoptosis in immature T cells in thymic cultures.

Authors:  C A Smith; G T Williams; R Kingston; E J Jenkinson; J J Owen
Journal:  Nature       Date:  1989-01-12       Impact factor: 49.962

2.  Genes encoding the T-cell receptor alpha and beta subunits are transcribed in an ordered manner during intrathymic ontogeny.

Authors:  H D Royer; D Ramarli; O Acuto; T J Campen; E L Reinherz
Journal:  Proc Natl Acad Sci U S A       Date:  1985-08       Impact factor: 11.205

3.  Functional competency of T cell antigen receptors in human thymus.

Authors:  A Weiss; P F Dazin; R Shields; S M Fu; L L Lanier
Journal:  J Immunol       Date:  1987-11-15       Impact factor: 5.422

4.  Class II major histocompatibility complex molecules regulate the development of the T4+T8- inducer phenotype of cultured human thymocytes.

Authors:  M L Blue; J F Daley; H Levine; S F Schlossman
Journal:  Proc Natl Acad Sci U S A       Date:  1985-12       Impact factor: 11.205

5.  Correlation of cell surface antigen expression on human thymocytes by multi-color flow cytometric analysis: implications for differentiation.

Authors:  L L Lanier; J P Allison; J H Phillips
Journal:  J Immunol       Date:  1986-10-15       Impact factor: 5.422

6.  Regulation of T-cell receptor gene expression in human T-cell development.

Authors:  M K Collins; G Tanigawa; A M Kissonerghis; M Ritter; K M Price; S Tonegawa; M J Owen
Journal:  Proc Natl Acad Sci U S A       Date:  1985-07       Impact factor: 11.205

Review 7.  The T cell receptor.

Authors:  P Marrack; J Kappler
Journal:  Science       Date:  1987-11-20       Impact factor: 47.728

8.  CD4+ murine T cells develop from CD8+ precursors in vivo.

Authors:  L Smith
Journal:  Nature       Date:  1987 Apr 23-29       Impact factor: 49.962

Review 9.  The differentiation and function of human T lymphocytes.

Authors:  E L Reinherz; S F Schlossman
Journal:  Cell       Date:  1980-04       Impact factor: 41.582

10.  Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes.

Authors:  P Kisielow; H Blüthmann; U D Staerz; M Steinmetz; H von Boehmer
Journal:  Nature       Date:  1988-06-23       Impact factor: 49.962
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  2 in total

1.  Downregulation of CD1 marks acquisition of functional maturation of human thymocytes and defines a control point in late stages of human T cell development.

Authors:  P Res; B Blom; T Hori; K Weijer; H Spits
Journal:  J Exp Med       Date:  1997-01-06       Impact factor: 14.307

2.  Selection by two powerful antigens may account for the presence of the major population of human peripheral gamma/delta T cells.

Authors:  G De Libero; G Casorati; C Giachino; C Carbonara; N Migone; P Matzinger; A Lanzavecchia
Journal:  J Exp Med       Date:  1991-06-01       Impact factor: 14.307
  2 in total

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