Literature DB >> 25013443

Murine Models of Polycystic Kidney Disease.

Luis Fernando Menezes1, Gregory George Germino1.   

Abstract

Polycystic diseases affect approximately 1/1000 and are important causes of kidney failure. No therapies presently are in clinical practice that can prevent disease progression. Multiple mouse models have been produced for the genetic forms of the disease that most commonly affect humans. In this report, we review recent progress in the field and describe some of the outstanding challenges.

Entities:  

Year:  2013        PMID： 25013443      PMCID： PMC4085131          DOI： 10.1016/j.ddmec.2013.10.002

Source DB:  PubMed          Journal:  Drug Discov Today Dis Mech        ISSN： 1740-6765


  64 in total

1.  A functional floxed allele of Pkd1 that can be conditionally inactivated in vivo.

Authors:  Klaus B Piontek; David L Huso; Alexander Grinberg; Lijuan Liu; Djahida Bedja; Haidan Zhao; Kathleen Gabrielson; Feng Qian; Changlin Mei; Heiner Westphal; Gregory G Germino
Journal:  J Am Soc Nephrol       Date:  2004-12       Impact factor: 10.121

2.  Biliary and pancreatic dysgenesis in mice harboring a mutation in Pkhd1.

Authors:  Anna-Rachel Gallagher; Ernie L Esquivel; Tiffany S Briere; Xin Tian; Michihiro Mitobe; Luis F Menezes; Glen S Markowitz; Dhanpat Jain; Luiz F Onuchic; Stefan Somlo
Journal:  Am J Pathol       Date:  2008-01-17       Impact factor: 4.307

3.  Functional polycystin-1 dosage governs autosomal dominant polycystic kidney disease severity.

Authors:  Katharina Hopp; Christopher J Ward; Cynthia J Hommerding; Samih H Nasr; Han-Fang Tuan; Vladimir G Gainullin; Sandro Rossetti; Vicente E Torres; Peter C Harris
Journal:  J Clin Invest       Date:  2012-10-15       Impact factor: 14.808

4.  Kidney cysts, pancreatic cysts, and biliary disease in a mouse model of autosomal recessive polycystic kidney disease.

Authors:  Scott S Williams; Patricia Cobo-Stark; Leighton R James; Stefan Somlo; Peter Igarashi
Journal:  Pediatr Nephrol       Date:  2008-02-20       Impact factor: 3.714

5.  Design, power, and interpretation of studies in the standard murine model of ALS.

Authors:  Sean Scott; Janice E Kranz; Jeff Cole; John M Lincecum; Kenneth Thompson; Nancy Kelly; Alan Bostrom; Jill Theodoss; Bashar M Al-Nakhala; Fernando G Vieira; Jeyanthi Ramasubbu; James A Heywood
Journal:  Amyotroph Lateral Scler       Date:  2008

6.  A critical developmental switch defines the kinetics of kidney cyst formation after loss of Pkd1.

Authors:  Klaus Piontek; Luis F Menezes; Miguel A Garcia-Gonzalez; David L Huso; Gregory G Germino
Journal:  Nat Med       Date:  2007-10-28       Impact factor: 53.440

7.  A mouse model of autosomal recessive polycystic kidney disease with biliary duct and proximal tubule dilatation.

Authors:  J R Woollard; R Punyashtiti; S Richardson; T V Masyuk; S Whelan; B Q Huang; D J Lager; J vanDeursen; V E Torres; V H Gattone; N F LaRusso; P C Harris; C J Ward
Journal:  Kidney Int       Date:  2007-05-23       Impact factor: 10.612

8.  Identification and characterization of Pkhd1, the mouse orthologue of the human ARPKD gene.

Authors:  Yasuyuki Nagasawa; Sonja Matthiesen; Luiz F Onuchic; Xiaoying Hou; Carsten Bergmann; Ernie Esquivel; Jan Senderek; Zhiyong Ren; Raoul Zeltner; Laszlo Furu; Ellis Avner; Markus Moser; Stefan Somlo; Lisa Guay-Woodford; Reinhard Büttner; Klaus Zerres; Gregory G Germino
Journal:  J Am Soc Nephrol       Date:  2002-09       Impact factor: 10.121

9.  Network analysis of a Pkd1-mouse model of autosomal dominant polycystic kidney disease identifies HNF4α as a disease modifier.

Authors:  Luis F Menezes; Fang Zhou; Andrew D Patterson; Klaus B Piontek; Kristopher W Krausz; Frank J Gonzalez; Gregory G Germino
Journal:  PLoS Genet       Date:  2012-11-29       Impact factor: 5.917

10.  Defective glucose metabolism in polycystic kidney disease identifies a new therapeutic strategy.

Authors:  Isaline Rowe; Marco Chiaravalli; Valeria Mannella; Valeria Ulisse; Giacomo Quilici; Monika Pema; Xuewen W Song; Hangxue Xu; Silvia Mari; Feng Qian; York Pei; Giovanna Musco; Alessandra Boletta
Journal:  Nat Med       Date:  2013-03-24       Impact factor: 53.440
View more
  7 in total

1.  Examining the Role of Novel CKD Therapies for the ADPKD Patient.

Authors:  Dipal M Patel; Neera K Dahl
Journal:  Kidney360       Date:  2021-03-24

2.  Differences in the timing and magnitude of Pkd1 gene deletion determine the severity of polycystic kidney disease in an orthologous mouse model of ADPKD.

Authors:  Kelly A Rogers; Sarah E Moreno; Laurie A Smith; Hervé Husson; Nikolay O Bukanov; Steven R Ledbetter; Yeva Budman; Yuefeng Lu; Bing Wang; Oxana Ibraghimov-Beskrovnaya; Thomas A Natoli
Journal:  Physiol Rep       Date:  2016-06

Review 3.  An Overview of In Vivo and In Vitro Models for Autosomal Dominant Polycystic Kidney Disease: A Journey from 3D-Cysts to Mini-Pigs.

Authors:  Svenja Koslowski; Camille Latapy; Pierrïck Auvray; Marc Blondel; Laurent Meijer
Journal:  Int J Mol Sci       Date:  2020-06-25       Impact factor: 5.923

4.  Deep learning is widely applicable to phenotyping embryonic development and disease.

Authors:  Thomas Naert; Özgün Çiçek; Paulina Ogar; Max Bürgi; Nikko-Ideen Shaidani; Michael M Kaminski; Yuxiao Xu; Kelli Grand; Marko Vujanovic; Daniel Prata; Friedhelm Hildebrandt; Thomas Brox; Olaf Ronneberger; Fabian F Voigt; Fritjof Helmchen; Johannes Loffing; Marko E Horb; Helen Rankin Willsey; Soeren S Lienkamp
Journal:  Development       Date:  2021-11-05       Impact factor: 6.868

5.  Ppia is the most stable housekeeping gene for qRT-PCR normalization in kidneys of three Pkd1-deficient mouse models.

Authors:  Juan J Muñoz; Ana C Anauate; Luiz F Onuchic; Ita P Heilberg; Andressa G Amaral; Frederico M Ferreira; Elieser H Watanabe; Renata Meca; Milene S Ormanji; Mirian A Boim
Journal:  Sci Rep       Date:  2021-10-05       Impact factor: 4.379

6.  A cAMP signalosome in primary cilia drives gene expression and kidney cyst formation.

Authors:  Jan N Hansen; Fabian Kaiser; Philipp Leyendecker; Birthe Stüven; Jens-Henning Krause; Fatemeh Derakhshandeh; Jaazba Irfan; Tommy J Sroka; Kenley M Preval; Paurav B Desai; Michael Kraut; Heidi Theis; Anna-Dorothee Drews; Elena De-Domenico; Kristian Händler; Gregory J Pazour; David J P Henderson; David U Mick; Dagmar Wachten
Journal:  EMBO Rep       Date:  2022-06-13       Impact factor: 9.071

7.  Disrupting polycystin-2 EF hand Ca2+ affinity does not alter channel function or contribute to polycystic kidney disease.

Authors:  Thuy N Vien; Leo C T Ng; Jessica M Smith; Ke Dong; Matteus Krappitz; Vladimir G Gainullin; Sorin Fedeles; Peter C Harris; Stefan Somlo; Paul G DeCaen
Journal:  J Cell Sci       Date:  2020-12-24       Impact factor: 5.235
  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.