Rune Borregaard1, Peter Lukac2, Christian Gerdes2, Dorthe Møller3, Peter Thomas Mortensen2, Lars Pedersen4, Jens Cosedis Nielsen2, Henrik Kjærulf Jensen2. 1. Department of Cardiology, Aarhus University Hospital Skejby, Brendstrupgaardsvej 100, DK-8200 Aarhus N, Denmark rbborregaard@ki.au.dk. 2. Department of Cardiology, Aarhus University Hospital Skejby, Brendstrupgaardsvej 100, DK-8200 Aarhus N, Denmark. 3. Department of Cardiology, Viborg Hospital, Heibergs Alle 4, DK-8800 Viborg, Denmark. 4. Department of Clinical Epidemiology, Aarhus University Hospital, Olof Palmes Alle 43, DK-8200 Aarhus N, Denmark.
Abstract
AIMS: To assess the long-term mortality and occurrence of post-ablation atrial fibrillation in patients undergoing a radiofrequency ablation for the Wolff-Parkinson-White (WPW) syndrome. METHODS AND RESULTS: A retrospective cohort study of patients (N = 362) subjected to radiofrequency ablation of the WPW syndrome at Aarhus University Hospital from 1990 to 2011. A comparison cohort (N = 3619) was generated from the Danish National Board of Health Central Population Registry. We found no significant difference in all-cause mortality when comparing the WPW group with the control group [hazard ratio (HR): 0.77 and confidence interval (CI): 0.47-1.25]. After radiofrequency ablation, the WPW group had a significantly higher risk of atrial fibrillation than the control group (HR: 4.77 and CI: 3.05-7.43). Atrial fibrillation prior to ablation (HR: 4.66 and CI: 2.09-10.41) and age over 50 years (HR: 9.79 and CI: 4.29-22.36) at the time of ablation were independent risk factors for post-ablation atrial fibrillation in the WPW group. CONCLUSION: Patients with radiofrequency ablation-treated WPW syndrome have a post-ablation mortality that is similar to the background population. The risk of atrial fibrillation remains high after radiofrequency ablation of the WPW syndrome. Published on behalf of the European Society of Cardiology. All rights reserved.
AIMS: To assess the long-term mortality and occurrence of post-ablation atrial fibrillation in patients undergoing a radiofrequency ablation for the Wolff-Parkinson-White (WPW) syndrome. METHODS AND RESULTS: A retrospective cohort study of patients (N = 362) subjected to radiofrequency ablation of the WPW syndrome at Aarhus University Hospital from 1990 to 2011. A comparison cohort (N = 3619) was generated from the Danish National Board of Health Central Population Registry. We found no significant difference in all-cause mortality when comparing the WPW group with the control group [hazard ratio (HR): 0.77 and confidence interval (CI): 0.47-1.25]. After radiofrequency ablation, the WPW group had a significantly higher risk of atrial fibrillation than the control group (HR: 4.77 and CI: 3.05-7.43). Atrial fibrillation prior to ablation (HR: 4.66 and CI: 2.09-10.41) and age over 50 years (HR: 9.79 and CI: 4.29-22.36) at the time of ablation were independent risk factors for post-ablation atrial fibrillation in the WPW group. CONCLUSION:Patients with radiofrequency ablation-treated WPW syndrome have a post-ablation mortality that is similar to the background population. The risk of atrial fibrillation remains high after radiofrequency ablation of the WPW syndrome. Published on behalf of the European Society of Cardiology. All rights reserved.
Authors: Zeynep H Coban-Akdemir; Wu-Lin Charng; Mahshid Azamian; Ingrid S Paine; Jaya Punetha; Christopher M Grochowski; Tomasz Gambin; Santiago O Valdes; Bryan Cannon; Gladys Zapata; Patricia P Hernandez; Shalini Jhangiani; Harsha Doddapaneni; Jianhong Hu; Fatima Boricha; Donna M Muzny; Eric Boerwinkle; Yaping Yang; Richard A Gibbs; Jennifer E Posey; Xander H T Wehrens; John W Belmont; Jeffrey J Kim; Christina Y Miyake; James R Lupski; Seema R Lalani Journal: Am J Med Genet A Date: 2020-03-31 Impact factor: 2.802