Vinita Takiar1, Dan S Gombos2, Firas Mourtada3, Laura A Rechner4, Ann A Lawyer4, William H Morrison1, Adam S Garden1, Beth M Beadle5. 1. Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas. 2. Department of Ophthalmology, University of Texas MD Anderson Cancer Center, Houston, Texas. 3. Department of Radiation Oncology, Christiana Care Health System, Helen F. Graham Cancer Center, Wilmington, Delaware and Department of Radiation Oncology, Thomas Jefferson University, Philadelphia, PA; Department of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston, Texas. 4. Department of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston, Texas. 5. Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas. Electronic address: bbeadle@mdanderson.org.
Abstract
PURPOSE: Ruthenium-106 ((106)Ru) eye plaques have the potential to achieve excellent tumor control with acceptable radiation toxicity. We evaluated our experience in the management of uveal melanoma treated with (106)Ru brachytherapy. METHODS AND MATERIALS: The records of 40 patients with uveal melanoma treated with brachytherapy using (106)Ru plaques from 2003 to 2007 at University of Texas MD Anderson Cancer Center were reviewed. Endpoints assessed included tumor control and toxicity. RESULTS: Median ophthalmologic follow-up was 67 months. Actuarial 5-year rates of local control (LC), progression-free survival (PFS), and overall survival (OS) were 97%, 94%, and 92%. There were 3 deaths, 2 related to melanoma. Fifteen patients experienced clinically significant visual loss; no patients were diagnosed with neovascular glaucoma, and 1 patient developed a clinically significant radiation-associated cataract. No patient required enucleation. CONCLUSIONS: We report the largest published US cohort of patients treated with (106)Ru plaque brachytherapy for uveal melanoma. Tumor control was excellent, and toxicity was acceptably low. These data support the reintroduction of (106)Ru into clinical practice for ocular melanoma.
PURPOSE:Ruthenium-106 ((106)Ru) eye plaques have the potential to achieve excellent tumor control with acceptable radiation toxicity. We evaluated our experience in the management of uveal melanoma treated with (106)Ru brachytherapy. METHODS AND MATERIALS: The records of 40 patients with uveal melanoma treated with brachytherapy using (106)Ru plaques from 2003 to 2007 at University of Texas MD Anderson Cancer Center were reviewed. Endpoints assessed included tumor control and toxicity. RESULTS: Median ophthalmologic follow-up was 67 months. Actuarial 5-year rates of local control (LC), progression-free survival (PFS), and overall survival (OS) were 97%, 94%, and 92%. There were 3 deaths, 2 related to melanoma. Fifteen patients experienced clinically significant visual loss; no patients were diagnosed with neovascular glaucoma, and 1 patient developed a clinically significant radiation-associated cataract. No patient required enucleation. CONCLUSIONS: We report the largest published US cohort of patients treated with (106)Ru plaque brachytherapy for uveal melanoma. Tumor control was excellent, and toxicity was acceptably low. These data support the reintroduction of (106)Ru into clinical practice for ocular melanoma.
Authors: Chandrani Chattopadhyay; Dae Won Kim; Dan S Gombos; Junna Oba; Yong Qin; Michelle D Williams; Bita Esmaeli; Elizabeth A Grimm; Jennifer A Wargo; Scott E Woodman; Sapna P Patel Journal: Cancer Date: 2016-03-15 Impact factor: 6.860
Authors: C Ellis Wisely; Mersiha Hadziahmetovic; Rachel E Reem; Erinn M Hade; Subir Nag; Frederick H Davidorf; Douglas Martin; Colleen M Cebulla Journal: Brachytherapy Date: 2016 Jan-Feb Impact factor: 2.362