Janine A Simons1, Urban M Fietzek2, Annika Waldmann3, Tobias Warnecke4, Tibor Schuster5, Andrés O Ceballos-Baumann2. 1. Institute for Social Medicine and Epidemiology, Universität zu Lübeck, Lübeck, Germany; Center for Parkinson's Disease and Movement Disorders, Schön Klinik München Schwabing (MSW), Munich, Germany. Electronic address: Janine.Simons@uksh.de. 2. Center for Parkinson's Disease and Movement Disorders, Schön Klinik München Schwabing (MSW), Munich, Germany. 3. Institute for Social Medicine and Epidemiology, Universität zu Lübeck, Lübeck, Germany. 4. Department of Neurology, University Hospital of Muenster, Muenster, Germany. 5. Institute of Medical Statistics and Epidemiology, Technische Universität München (TUM), Munich, Germany.
Abstract
BACKGROUND: Dysphagia in patients with Parkinson's disease (PD) significantly reduces quality of life and predicted lifetime. Current screening procedures are insufficiently evaluated. We aimed to develop and validate a patient-reported outcome questionnaire for early diagnosis of dysphagia in patients with PD. METHODS: The two-phased project comprised the questionnaire, diagnostic scales construction (N = 105), and a validation study (N = 82). Data for the project were gathered from PD patients at a German Movement Disorder Center. For validation purposes, a clinical evaluation focusing on swallowing tests, tests of sensory reflexes, and fiberoptic endoscopic evaluation of swallowing (FEES) was performed that yielded a criteria sum score against which the results of the questionnaire were compared. Specificity and sensitivity were evaluated for the detection of noticeable dysphagia and for the risk of aspiration. RESULTS: The Munich Dysphagia Test - Parkinson's disease (MDT-PD) consists of 26 items that show high internal consistency (α = 0.91). For the validation study, 82 patients, aged 70.9 ± 8.7 (mean ± SD), with a median Hoehn & Yahr stage of 3, were assessed. 73% of patients had dysphagia with noticeable oropharyngeal symptoms (44%) or with penetration/aspiration (29%). The criteria sum score correlated positively with the screening result (r = 0.70, p < 0.001). The MDT-PD sum score classified not noticeable dysphagia vs. risk of aspiration (noticeable dysphagia) with a sensitivity of 90% (82%) and a specificity of 86% (71%), and yielded similar results in cross-validation, respectively. CONCLUSIONS: MDT-PD is a valid screening tool for early diagnosis of swallowing problems and aspiration risk, as well as initial graduation of dysphagia severity in PD patients.
BACKGROUND:Dysphagia in patients with Parkinson's disease (PD) significantly reduces quality of life and predicted lifetime. Current screening procedures are insufficiently evaluated. We aimed to develop and validate a patient-reported outcome questionnaire for early diagnosis of dysphagia in patients with PD. METHODS: The two-phased project comprised the questionnaire, diagnostic scales construction (N = 105), and a validation study (N = 82). Data for the project were gathered from PDpatients at a German Movement Disorder Center. For validation purposes, a clinical evaluation focusing on swallowing tests, tests of sensory reflexes, and fiberoptic endoscopic evaluation of swallowing (FEES) was performed that yielded a criteria sum score against which the results of the questionnaire were compared. Specificity and sensitivity were evaluated for the detection of noticeable dysphagia and for the risk of aspiration. RESULTS: The Munich Dysphagia Test - Parkinson's disease (MDT-PD) consists of 26 items that show high internal consistency (α = 0.91). For the validation study, 82 patients, aged 70.9 ± 8.7 (mean ± SD), with a median Hoehn & Yahr stage of 3, were assessed. 73% of patients had dysphagia with noticeable oropharyngeal symptoms (44%) or with penetration/aspiration (29%). The criteria sum score correlated positively with the screening result (r = 0.70, p < 0.001). The MDT-PD sum score classified not noticeable dysphagia vs. risk of aspiration (noticeable dysphagia) with a sensitivity of 90% (82%) and a specificity of 86% (71%), and yielded similar results in cross-validation, respectively. CONCLUSIONS: MDT-PD is a valid screening tool for early diagnosis of swallowing problems and aspiration risk, as well as initial graduation of dysphagia severity in PDpatients.
Authors: Claudio A R Gomes; Régis B Andriolo; Cathy Bennett; Suzana A S Lustosa; Delcio Matos; Daniel R Waisberg; Jaques Waisberg Journal: Cochrane Database Syst Rev Date: 2015-05-22
Authors: Rainer Wirth; Rainer Dziewas; Anne Marie Beck; Pere Clavé; Shaheen Hamdy; Hans Juergen Heppner; Susan Langmore; Andreas Herbert Leischker; Rosemary Martino; Petra Pluschinski; Alexander Rösler; Reza Shaker; Tobias Warnecke; Cornel Christian Sieber; Dorothee Volkert Journal: Clin Interv Aging Date: 2016-02-23 Impact factor: 4.458