Maurizio Pompili1, Marco Innamorati1, Xenia Gonda2, Denise Erbuto1, Alberto Forte1, Federica Ricci1, David Lester3, Hagop S Akiskal4, Gustavo H Vázquez5, Zoltan Rihmer6, Mario Amore7, Paolo Girardi1. 1. Department of Neurosciences, Mental Health and Sensory Organs, Suicide Prevention Center, Sant׳Andrea Hospital, Sapienza University of Rome, Italy. 2. Department of Clinical and Theoretical Mental Health, Kútvölgyi Clinical Center, Semmelweis University, Budapest, Hungary; Laboratory of Suicide Prevention and Research, National Institute for Psychiatry and Addictology; Department of Pharmacology and Pharmacotherapy, Semmelweis University; MTA-SE Neurohemistry Research Group. 3. Laboratory of Suicide Prevention and Research, National Institute for Psychiatry and Addictology; The Richard Stockton College of New Jersey, Pomona, NJ, USA. 4. International Mood Center, La Jolla, California, USA; San Diego Veterans Administration Medical Center, San Diego, California, USA. 5. Department of Neuroscience, University of Palermo, Buenos Aires, Argentina; International Consortium for Bipolar and Psychotic Disorder Research, McLean Hospital, Belmont, MA, USA. 6. Department of Clinical and Theoretical Mental Health, Kútvölgyi Clinical Center, Semmelweis University, Budapest, Hungary; Laboratory of Suicide Prevention and Research, National Institute for Psychiatry and Addictology. 7. Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, Section of Psychiatry, University of Genova, Genova, Italy.
Abstract
BACKGROUND: Mood disorders (MD) are disabling conditions throughout the world associated with significant psychosocial impairment. Affective temperaments, as well as hopelessness, may play a significant role in the pathophysiology of MD. The present study was designed to characterize patients with MD for their prevalent affective temperament and level of hopelessness. METHODS: Five hundred fifty-nine (253 men and 306 women) consecutive adult inpatients were assessed using the Temperament Evaluation of Memphis, Pisa, Paris and San Diego-Autoquestionnaire version (TEMPS-A), the Gotland Scale for Male Depression (GSMD), the Beck Hopelessness Scale (BHS) and the Mini International Neuropsychiatric Interview (MINI). RESULTS: Higher cyclothymia and irritable temperaments were found in bipolar disorder-I (BD-I) patients compared to those with other Axis I diagnoses. Major depressive disorder (MDD) patients had lower hyperthymia than BD-I and BD-II patients and higher anxiety than patients with other Axis I diagnoses. Severe "male" depression was more common in BD-II patients compared to BD-I and MDD patients. BD-I patients and those with other axis I diagnoses reported lower BHS ≥9 scores than those with BD-II and MDD. LIMITATIONS: The study had the limitations of all naturalistic designs, that is, potentially relevant variables were not addressed. Furthermore, the cross-sectional nature of the study did not allow conclusions about causation, and the use of self-report measures could be potentially biased by social desirability. CONCLUSION: MDD patients were more likely to have higher anxious temperament, higher hopelessness and lower hyperthymic temperament scores, while BD-I patients more often had cyclothymic and irritable temperaments than patients with other Axis I diagnoses. The implications of the present results were discussed.
BACKGROUND:Mood disorders (MD) are disabling conditions throughout the world associated with significant psychosocial impairment. Affective temperaments, as well as hopelessness, may play a significant role in the pathophysiology of MD. The present study was designed to characterize patients with MD for their prevalent affective temperament and level of hopelessness. METHODS: Five hundred fifty-nine (253 men and 306 women) consecutive adult inpatients were assessed using the Temperament Evaluation of Memphis, Pisa, Paris and San Diego-Autoquestionnaire version (TEMPS-A), the Gotland Scale for Male Depression (GSMD), the Beck Hopelessness Scale (BHS) and the Mini International Neuropsychiatric Interview (MINI). RESULTS: Higher cyclothymia and irritable temperaments were found in bipolar disorder-I (BD-I) patients compared to those with other Axis I diagnoses. Major depressive disorder (MDD) patients had lower hyperthymia than BD-I and BD-II patients and higher anxiety than patients with other Axis I diagnoses. Severe "male" depression was more common in BD-II patients compared to BD-I and MDDpatients. BD-I patients and those with other axis I diagnoses reported lower BHS ≥9 scores than those with BD-II and MDD. LIMITATIONS: The study had the limitations of all naturalistic designs, that is, potentially relevant variables were not addressed. Furthermore, the cross-sectional nature of the study did not allow conclusions about causation, and the use of self-report measures could be potentially biased by social desirability. CONCLUSION:MDDpatients were more likely to have higher anxious temperament, higher hopelessness and lower hyperthymic temperament scores, while BD-I patients more often had cyclothymic and irritable temperaments than patients with other Axis I diagnoses. The implications of the present results were discussed.
Authors: Michał Panek; Mateusz Jonakowski; Jan Zioło; Tadeusz Pietras; Łukasz Wieteska; Beata Małachowska; Łukasz Mokros; Janusz Szemraj; Piotr Kuna Journal: Mol Neurobiol Date: 2016-02-13 Impact factor: 5.590
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Authors: Andrea László; Ádám Tabák; Beáta Kőrösi; Dániel Eörsi; Péter Torzsa; Orsolya Cseprekál; András Tislér; György Reusz; Zsófia Nemcsik-Bencze; Xénia Gonda; Zoltán Rihmer; János Nemcsik Journal: BMC Cardiovasc Disord Date: 2016-08-08 Impact factor: 2.298