Hong Jin Jeon1, Jong-Ik Park2, Maurizio Fava3, David Mischoulon3, Jee Hoon Sohn4, Sujeong Seong4, Jee Eun Park4, Ikki Yoo5, Maeng Je Cho6. 1. Department of Psychiatry, Depression Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea; Samsung Advanced Institute for Health Sciences & Technology (SAIHST), Seoul, South Korea; Depression Clinical and Research Program, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. 2. Department of Psychiatry, Kangwon National University College of Medicine, Chuncheon, South Korea. 3. Depression Clinical and Research Program, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. 4. Department of Psychiatry & Behavioral Science, Seoul National University College of Medicine, 28 Yeongeon-dong, Chongno-gu, Seoul 110-744, South Korea. 5. Department of Psychiatry, Depression Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea. 6. Department of Psychiatry & Behavioral Science, Seoul National University College of Medicine, 28 Yeongeon-dong, Chongno-gu, Seoul 110-744, South Korea. Electronic address: mjcho@snu.ac.kr.
Abstract
BACKGROUND: Major depressive disorder (MDD) and traumatic experience are independent risk factors for lifetime suicide attempt (LSA). However, the relationships between trauma history and depressive symptomatology as they relate to LSA are not fully understood. METHODS: A total of 12,532 adults, randomly selected through one-person-per-household method, completed a face-to-face interview using the Korean version of Composite International Diagnostic Interview (K-CIDI) and a questionnaire for LSA (response rate 80.2%). RESULTS: Among 825 subjects with MDD, 141 subjects reported an LSA (17.1%). LSAs were significantly greater in those who had experienced any trauma than in those who had not (χ(2)=34.66, p<0.0001). Multivariate logistic regression showed that only feelings of worthlessness were significantly associated with LSA among 20 depression symptoms in individuals with MDD (AOR=3.08, 95% CI 1.70-5.60). Feelings of worthlessness was associated with LSA in those who had experienced serious trauma (AOR=5.02, 95% CI 3.35-7.52), but not in those who had not. Serious traumas associated with LSA included military combat, witnessing a violent crime, rape or sexual assault, a bad beating, being threatened by others, and learning about traumas to others. Serious trauma showed no significant association with LSA in those who did not have feelings of worthlessness. PTSD was a comorbidity that showed the highest odds ratio with LSA in individuals with MDD. CONCLUSIONS: Feelings of worthlessness are more strongly associated with LSA than other depression symptoms in individuals with MDD, and it is significantly associated with LSA in those who experienced serious trauma but not in those who did not.
BACKGROUND: Major depressive disorder (MDD) and traumatic experience are independent risk factors for lifetime suicide attempt (LSA). However, the relationships between trauma history and depressive symptomatology as they relate to LSA are not fully understood. METHODS: A total of 12,532 adults, randomly selected through one-person-per-household method, completed a face-to-face interview using the Korean version of Composite International Diagnostic Interview (K-CIDI) and a questionnaire for LSA (response rate 80.2%). RESULTS: Among 825 subjects with MDD, 141 subjects reported an LSA (17.1%). LSAs were significantly greater in those who had experienced any trauma than in those who had not (χ(2)=34.66, p<0.0001). Multivariate logistic regression showed that only feelings of worthlessness were significantly associated with LSA among 20 depression symptoms in individuals with MDD (AOR=3.08, 95% CI 1.70-5.60). Feelings of worthlessness was associated with LSA in those who had experienced serious trauma (AOR=5.02, 95% CI 3.35-7.52), but not in those who had not. Serious traumas associated with LSA included military combat, witnessing a violent crime, rape or sexual assault, a bad beating, being threatened by others, and learning about traumas to others. Serious trauma showed no significant association with LSA in those who did not have feelings of worthlessness. PTSD was a comorbidity that showed the highest odds ratio with LSA in individuals with MDD. CONCLUSIONS: Feelings of worthlessness are more strongly associated with LSA than other depression symptoms in individuals with MDD, and it is significantly associated with LSA in those who experienced serious trauma but not in those who did not.
Authors: Maria Andreu Pascual; Jessica C Levenson; John Merranko; Mary Kay Gill; Heather Hower; Shirley Yen; Michael Strober; Tina R Goldstein; Benjamin I Goldstein; Neal D Ryan; Lauren M Weinstock; Martin B Keller; David Axelson; Boris Birmaher Journal: J Affect Disord Date: 2020-05-22 Impact factor: 4.839
Authors: Hyewon Kim; Yuwon Kim; Myung-Hee Shin; Yoo-Jung Park; Hyung-Eun Park; Maurizio Fava; David Mischoulon; Mi Jin Park; Eun Ji Kim; Hong Jin Jeon Journal: Front Psychiatry Date: 2022-09-06 Impact factor: 5.435