Literature DB >> 25011387

Interleukin-6 in renal disease and therapy.

Simon A Jones1, Donald J Fraser2, Ceri A Fielding3, Gareth W Jones3.   

Abstract

Interleukin (IL)-6 has become a major target for clinical intervention in various autoimmune conditions. Here, drugs including the humanized anti-IL-6 receptor (IL-6R) antibody tocilizumab emphasize the clinical importance of IL-6 in driving disease and poor patient outcomes. During the course of this review, we will outline the biology surrounding IL-6 and discuss the impact of IL-6 in renal disease and the clinical complications associated with renal replacement therapies and transplantation. We will also consider the merit of IL-6 measurement as a prognostic indicator and provide a clinical perspective on IL-6-blocking therapies in renal disease.
© The Author 2014. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved.

Entities:  

Keywords:  cytokines; interleukin-6; renal disease; therapy

Mesh：

Substances：

Year:  2014        PMID： 25011387     DOI： 10.1093/ndt/gfu233

Source DB:  PubMed          Journal:  Nephrol Dial Transplant        ISSN： 0931-0509            Impact factor:   5.992


  27 in total

1.  Plasma IL-6 and IL-10 Concentrations Predict AKI and Long-Term Mortality in Adults after Cardiac Surgery.

Authors:  William R Zhang; Amit X Garg; Steven G Coca; Philip J Devereaux; John Eikelboom; Peter Kavsak; Eric McArthur; Heather Thiessen-Philbrook; Colleen Shortt; Michael Shlipak; Richard Whitlock; Chirag R Parikh
Journal:  J Am Soc Nephrol       Date:  2015-04-08       Impact factor: 10.121

2.  Knockout of the neonatal Fc receptor in cultured podocytes alters IL-6 signaling and the actin cytoskeleton.

Authors:  Pantipa Tonsawan; James Dylewski; Linda Lewis; Judith Blaine
Journal:  Am J Physiol Cell Physiol       Date:  2019-09-25       Impact factor: 4.249

3.  IL-6 Trans-Signaling Drives Murine Crescentic GN.

Authors:  Gerald S Braun; Yoshikuni Nagayama; Yuichi Maruta; Felix Heymann; Claudia R van Roeyen; Barbara M Klinkhammer; Peter Boor; Luigi Villa; David J Salant; Ute Raffetseder; Stefan Rose-John; Tammo Ostendorf; Jürgen Floege
Journal:  J Am Soc Nephrol       Date:  2015-06-03       Impact factor: 10.121

Review 4.  Immunosuppressive Medications.

Authors:  Alexander C Wiseman
Journal:  Clin J Am Soc Nephrol       Date:  2015-07-13       Impact factor: 8.237

5.  Effect of tocilizumab, an interleukin-6 inhibitor, on early stage streptozotocin-induced diabetic nephropathy in rats.

Authors:  Aly M Abdelrahman; Yousuf Al Suleimani; Asem Shalaby; Mohammed Ashique; Priyadarsini Manoj; Badreldin H Ali
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2019-04-25       Impact factor: 3.000

Review 6.  T cells and autoimmune kidney disease.

Authors:  Abel Suárez-Fueyo; Sean J Bradley; David Klatzmann; George C Tsokos
Journal:  Nat Rev Nephrol       Date:  2017-03-13       Impact factor: 28.314

7.  The Association between Cytokines and 365-Day Readmission or Mortality in Adult Cardiac Surgery.

Authors:  Allen D Everett; Shama S Alam; Sherry L Owens; Devin M Parker; Christine Goodrich; Donald S Likosky; Heather Thiessen-Philbrook; Moritz Wyler von Ballmoos; Kevin Lobdell; Todd A MacKenzie; Jeffrey Jacobs; Chirag R Parikh; Anthony W DiScipio; David J Malenka; Jeremiah R Brown
Journal:  J Extra Corpor Technol       Date:  2019-12

8.  Biocompatible Solutions and Long-Term Changes in Peritoneal Solute Transport.

Authors:  Emma H Elphick; Lucy Teece; James A Chess; Jun-Young Do; Yong-Lim Kim; H Bahl Lee; Sara N Davison; Nicholas Topley; Simon J Davies; Mark Lambie
Journal:  Clin J Am Soc Nephrol       Date:  2018-08-31       Impact factor: 8.237

Review 9.  Role of Macrophages and Related Cytokines in Kidney Disease.

Authors:  Elena Cantero-Navarro; Sandra Rayego-Mateos; Macarena Orejudo; Lucía Tejedor-Santamaria; Antonio Tejera-Muñoz; Ana Belén Sanz; Laura Marquez-Exposito; Vanessa Marchant; Laura Santos-Sanchez; Jesús Egido; Alberto Ortiz; Teresa Bellon; Raúl R Rodrigues-Diez; Marta Ruiz-Ortega
Journal:  Front Med (Lausanne)       Date:  2021-07-08

Review 10.  Plasma cell biology: Foundations for targeted therapeutic development in transplantation.

Authors:  Amy P Rossi; Rita R Alloway; David Hildeman; E Steve Woodle
Journal:  Immunol Rev       Date:  2021-07-12       Impact factor: 10.983
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