Literature DB >> 25010799

Polyphosphate: a new player in the field of hemostasis.

Stephanie A Smith1, James H Morrissey.   

Abstract

PURPOSE OF REVIEW: Polyphosphate (polyP) is an inorganic polymer that has recently been shown to be secreted by activated platelets. It is a potent modulator of the blood clotting and complement systems in hemostasis, thrombosis, and inflammation. RECENT
FINDINGS: This review focuses on what is currently known about which blood cells secrete polyP, and the roles that polyP plays in modulating the blood clotting and complement systems in health and disease.
SUMMARY: PolyP is a novel player in normal hemostasis and likely plays roles in thrombotic diseases and also in host responses to pathogens. It is also potentially a drug target, as its contributions to hemostasis appear to be to accelerate blood clotting but are not required for blood clotting to happen.

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Year:  2014        PMID： 25010799      PMCID： PMC4415375          DOI： 10.1097/MOH.0000000000000069

Source DB:  PubMed          Journal:  Curr Opin Hematol        ISSN： 1065-6251            Impact factor:   3.284


  73 in total

1.  Inorganic polyphosphate and specific induction of apoptosis in human plasma cells.

Authors:  Laura Hernandez-Ruiz; Inés González-García; Carmen Castro; José A Brieva; Felix A Ruiz
Journal:  Haematologica       Date:  2006-09       Impact factor: 9.941

Review 2.  Intrinsic pathway of coagulation and arterial thrombosis.

Authors:  David Gailani; Thomas Renné
Journal:  Arterioscler Thromb Vasc Biol       Date:  2007-10-04       Impact factor: 8.311

3.  Levels of intrinsic coagulation factors and the risk of myocardial infarction among men: Opposite and synergistic effects of factors XI and XII.

Authors:  Carine J M Doggen; Frits R Rosendaal; Joost C M Meijers
Journal:  Blood       Date:  2006-08-24       Impact factor: 22.113

4.  Extracellular RNA constitutes a natural procoagulant cofactor in blood coagulation.

Authors:  Christian Kannemeier; Aya Shibamiya; Fumie Nakazawa; Heidi Trusheim; Clemens Ruppert; Philipp Markart; Yutong Song; Eleni Tzima; Elisabeth Kennerknecht; Michael Niepmann; Marie-Luise von Bruehl; Daniel Sedding; Steffen Massberg; Andreas Günther; Bernd Engelmann; Klaus T Preissner
Journal:  Proc Natl Acad Sci U S A       Date:  2007-04-03       Impact factor: 11.205

5.  Polyphosphate is a novel pro-inflammatory regulator of mast cells and is located in acidocalcisomes.

Authors:  David Moreno-Sanchez; Laura Hernandez-Ruiz; Felix A Ruiz; Roberto Docampo
Journal:  J Biol Chem       Date:  2012-07-03       Impact factor: 5.157

6.  The contact system--a novel branch of innate immunity generating antibacterial peptides.

Authors:  Inga-Maria Frick; Per Akesson; Heiko Herwald; Matthias Mörgelin; Martin Malmsten; Dorit K Nägler; Lars Björck
Journal:  EMBO J       Date:  2006-11-09       Impact factor: 11.598

7.  Polyphosphate blocks tumour metastasis via anti-angiogenic activity.

Authors:  Kyu Yeon Han; Bok Sil Hong; Yae Jin Yoon; Chang Min Yoon; Yoon-Keun Kim; Young-Guen Kwon; Yong Song Gho
Journal:  Biochem J       Date:  2007-08-15       Impact factor: 3.857

8.  Inhibition of polyphosphate as a novel strategy for preventing thrombosis and inflammation.

Authors:  Stephanie A Smith; Sharon H Choi; Julie N R Collins; Richard J Travers; Brian C Cooley; James H Morrissey
Journal:  Blood       Date:  2012-09-11       Impact factor: 22.113

9.  Nucleic acid scavengers inhibit thrombosis without increasing bleeding.

Authors:  Shashank Jain; George A Pitoc; Eda K Holl; Ying Zhang; Luke Borst; Kam W Leong; Jaewoo Lee; Bruce A Sullenger
Journal:  Proc Natl Acad Sci U S A       Date:  2012-07-25       Impact factor: 11.205

Review 10.  Polyphosphate and its diverse functions in host cells and pathogens.

Authors:  Silvia N J Moreno; Roberto Docampo
Journal:  PLoS Pathog       Date:  2013-05-02       Impact factor: 6.823
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  17 in total

Review 1.  Polyphosphate, platelets, and coagulation.

Authors:  R J Travers; S A Smith; J H Morrissey
Journal:  Int J Lab Hematol       Date:  2015-05       Impact factor: 2.877

Review 2.  Factor XI and contact activation as targets for antithrombotic therapy.

Authors:  D Gailani; C E Bane; A Gruber
Journal:  J Thromb Haemost       Date:  2015-06-16       Impact factor: 5.824

Review 3.  Oxidative stress protection by polyphosphate--new roles for an old player.

Authors:  Michael J Gray; Ursula Jakob
Journal:  Curr Opin Microbiol       Date:  2015-01-10       Impact factor: 7.934

4.  Correlation between factor (F)XIa, FIXa and tissue factor and trauma severity.

Authors:  Shannon M Prior; Mitchell J Cohen; Amanda S Conroy; Mary F Nelson; Lucy Z Kornblith; Benjamin M Howard; Saulius Butenas
Journal:  J Trauma Acute Care Surg       Date:  2017-06       Impact factor: 3.313

Review 5.  Protein quality control under oxidative stress conditions.

Authors:  Jan-Ulrik Dahl; Michael J Gray; Ursula Jakob
Journal:  J Mol Biol       Date:  2015-02-16       Impact factor: 5.469

Review 6.  Bacterial Defense Systems against the Neutrophilic Oxidant Hypochlorous Acid.

Authors:  Sadia Sultana; Alessandro Foti; Jan-Ulrik Dahl
Journal:  Infect Immun       Date:  2020-06-22       Impact factor: 3.441

7.  Polyphosphate is a novel cofactor for regulation of complement by a serpin, C1 inhibitor.

Authors:  Lakshmi C Wijeyewickrema; Emilie Lameignere; Lilian Hor; Renee C Duncan; Toshikazu Shiba; Richard J Travers; Piyushkumar R Kapopara; Victor Lei; Stephanie A Smith; Hugh Kim; James H Morrissey; Robert N Pike; Edward M Conway
Journal:  Blood       Date:  2016-06-23       Impact factor: 22.113

8.  Inhibition of IP6K1 suppresses neutrophil-mediated pulmonary damage in bacterial pneumonia.

Authors:  Qingming Hou; Fei Liu; Anutosh Chakraborty; Yonghui Jia; Amit Prasad; Hongbo Yu; Li Zhao; Keqiang Ye; Solomon H Snyder; Yuanfu Xu; Hongbo R Luo
Journal:  Sci Transl Med       Date:  2018-04-04       Impact factor: 17.956

9.  Basophil Blood Cell Count Is Associated With Enhanced Factor II Plasma Coagulant Activity and Increased Risk of Mortality in Patients With Stable Coronary Artery Disease: Not Only Neutrophils as Prognostic Marker in Ischemic Heart Disease.

Authors:  Francesca Pizzolo; Annalisa Castagna; Oliviero Olivieri; Domenico Girelli; Simonetta Friso; Filippo Stefanoni; Silvia Udali; Veronica Munerotto; Marcello Baroni; Vera Cetera; Giovanni Battista Luciani; Giuseppe Faggian; Francesco Bernardi; Nicola Martinelli
Journal:  J Am Heart Assoc       Date:  2021-02-24       Impact factor: 5.501

Review 10.  Is there a link between inorganic polyphosphate (polyP), mitochondria, and neurodegeneration?

Authors:  Emily A Borden; Matthew Furey; Nicholas J Gattone; Vedangi D Hambardikar; Xiao Hua Liang; Ernest R Scoma; Antonella Abou Samra; LaKeshia R D-Gary; Dayshaun J Dennis; Daniel Fricker; Cindy Garcia; ZeCheng Jiang; Shariq A Khan; Dheenadhayalan Kumarasamy; Hasmitha Kuppala; Savannah Ringrose; Evan J Rosenheim; Kimberly Van Exel; Hemanth Sai Vudhayagiri; Jiarui Zhang; Zhaowen Zhang; Mariona Guitart-Mampel; Pedro Urquiza; Maria E Solesio
Journal:  Pharmacol Res       Date:  2020-10-01       Impact factor: 7.658
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