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Literature DB >> 25010269

Identification of two novel functional p53 responsive elements in the herpes simplex virus-1 genome.

Jui-Cheng Hsieh¹, Ryan Kuta², Courtney R Armour², Paul E Boehmer².

Abstract

Analysis of the herpes simplex virus-1 (HSV-1) genome reveals two candidate p53 responsive elements (p53RE), located in proximity to the replication origins oriL and oriS, referred to as p53RE-L and p53RE-S, respectively. The sequences of p53RE-L and p53RE-S conform to the p53 consensus site and are present in HSV-1 strains KOS, 17, and F. p53 binds to both elements in vitro and in virus-infected cells. Both p53RE-L and p53RE-S are capable of conferring p53-dependent transcriptional activation onto a heterologous reporter gene. Importantly, expression of the essential immediate early viral transactivator ICP4 and the essential DNA replication protein ICP8, that are adjacent to p53RE-S and p53RE-L, are repressed in a p53-dependent manner. Taken together, this study identifies two novel functional p53RE in the HSV-1 genome and suggests a complex mechanism of viral gene regulation by p53 which may determine progression of the lytic viral replication cycle or the establishment of latency.

Entities: CellLine Chemical Disease Gene Species

Keywords: Gene expression; Herpes simplex virus 1; Responsive elements; p53

Mesh：

Substances：

Year: 2014 PMID： 25010269 PMCID： PMC4090806 DOI： 10.1016/j.virol.2014.04.019

Source DB: PubMed Journal: Virology ISSN： 0042-6822 Impact factor: 3.616

52 in total

1. Hepatitis B virus X mutants derived from human hepatocellular carcinoma retain the ability to abrogate p53-induced apoptosis.

Authors: T I Huo; X W Wang; M Forgues; C G Wu; E A Spillare; C Giannini; C Brechot; C C Harris
Journal: Oncogene Date: 2001-06-21 Impact factor: 9.867

3. Host cell p53 associates with the feline calicivirus major viral capsid protein VP1, the protease-polymerase NS6/7, and the double-stranded RNA playing a role in virus replication.

Authors: Adrian Trujillo-Uscanga; Ana Lorena Gutiérrez-Escolano
Journal: Virology Date: 2020-08-27 Impact factor: 3.616

3 in total

Identification of two novel functional p53 responsive elements in the herpes simplex virus-1 genome.

1. Hepatitis B virus X mutants derived from human hepatocellular carcinoma retain the ability to abrogate p53-induced apoptosis.

2. A transcriptionally active DNA-binding site for human p53 protein complexes.

3. Cancer. p53, guardian of the genome.

Review 4. Roles for p53 in growth arrest and apoptosis: putting on the brakes after genotoxic stress.

5. SV40 T antigen abrogates p53-mediated transcriptional activity.

6. Caspase 10 levels are increased following DNA damage in a p53-dependent manner.

7. The DNA-binding domain of p53 contains the four conserved regions and the major mutation hot spots.

8. Inhibition of p53 transactivation required for transformation by adenovirus early 1B protein.

9. Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations.

10. Roles of p53 in herpes simplex virus 1 replication.

1. p53 Is a Host Cell Regulator during Herpes Simplex Encephalitis.

Review 2. p53 and the Viral Connection: Back into the Future ^‡.

3. Host cell p53 associates with the feline calicivirus major viral capsid protein VP1, the protease-polymerase NS6/7, and the double-stranded RNA playing a role in virus replication.

Review 4. Roles for p53 in growth arrest and apoptosis: putting on the brakes after genotoxic stress.

Review 2. p53 and the Viral Connection: Back into the Future ‡.

Review 2. p53 and the Viral Connection: Back into the Future ^‡.