| Literature DB >> 25009408 |
Renata dos Santos Lugao1, Marina Pamponet Motta1, Matheus Freitas Cardoso de Azevedo1, Roque Gabriel Rezende de Lima1, Flávia de Azevedo Abrantes1, Edson Abdala1, Flair José Carrilho1, Daniel Ferraz de Campos Mazo1.
Abstract
A variety of clinical manifestations are associated directly or indirectly with tuberculosis. Among them, haematological abnormalities can be found in both the pulmonary and extrapulmonary forms of the disease. We report a case of immune thrombocytopenic purpura (ITP) associated with intestinal tuberculosis in a liver transplant recipient. The initial management of thrombocytopenia, with steroids and intravenous immunoglobulin, was not successful, and the lack of tuberculosis symptoms hampered a proper diagnostic evaluation. After the diagnosis of intestinal tuberculosis and the initiation of specific treatment, a progressive increase in the platelet count was observed. The mechanism of ITP associated with tuberculosis has not yet been well elucidated, but this condition should be considered in cases of ITP that are unresponsive to steroids and intravenous immunoglobulin, especially in immunocompromised patients and those from endemic areas.Entities:
Keywords: Immune thrombocytopenic purpura; Intestinal tuberculosis; Liver transplant; Thrombocytopenia; Tuberculosis
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Year: 2014 PMID: 25009408 PMCID: PMC4081708 DOI: 10.3748/wjg.v20.i25.8304
Source DB: PubMed Journal: World J Gastroenterol ISSN: 1007-9327 Impact factor: 5.742