Parallel functional reorganizations of somatosensory areas 3b and 1, and S2 following spinal cord injury in squirrel monkeys.

Multiple somatosensory cortices of adult primates reorganize following spinal cord injury, but little is known about the temporal dynamics and inter-areal differences of the reorganization. Using longitudinal high-resolution fMRI in combination with microelectrode recordings and tracer histology, we previously illustrated a two-phase dynamic spatial reorganization of digit representations in area 3b within weeks after a unilateral lesion of the dorsal column in squirrel monkeys (Chen et al., 2012). Here we report that higher-order area 1 and secondary somatosensory cortex (S2) underwent similar spatial reorganizations, which were characterized by shifted and expanded digit activations at week 4 after lesion, which then shifted back and contracted by week 8. In addition, the responsiveness of areas 3b and 1, and S2, as measured by the magnitude of the BOLD signal change to tactile stimuli, was reduced markedly at 4 weeks and then recovered to ~50% of the prelesion level at 8 weeks, a time when behavioral recovery was complete, as assessed by successful food retrieval rates. Across animals, the extents of spatial reorganizations and changes in cortical responsiveness and activation sizes in all three areas were correlated with the degree of afferent disruption. In summary, our data show that more severe afferent disruption was associated with greater cortical plasticity and behavioral impairment. Reorganization that occurred in area 3b, area 1, and S2 were similar across most measures.