K Hashimoto1, H Tsuda2, F Koizumi3, C Shimizu1, K Yonemori1, M Ando1, M Kodaira1, M Yunokawa1, Y Fujiwara1, K Tamura4. 1. Department of Breast and Medical Oncology, National Cancer Center Hospital, Tokyo, Japan. 2. Department of Pathology and Clinical Laboratories, National Cancer Center Hospital, Tokyo, Japan. 3. Shien-laboratory, National Cancer Center Hospital, Tokyo, Japan. 4. Department of Breast and Medical Oncology, National Cancer Center Hospital, Tokyo, Japan ketamura@ncc.go.jp.
Abstract
BACKGROUND: Triple-negative breast cancer (TNBC) patients are a poor prognostic subgroup, and currently, there is no biomarker for targeted therapy. PATIENTS AND METHODS: Tissue samples were obtained from 75 TNBC patients with lymph-node metastases who had received adjuvant chemotherapy. We examined 11 biomarkers, including PIK3CA and AKT1mutation, with regard to event-free survival (EFS) and overall survival (OS) of patients. RESULTS: In the tumor tissues, phospho-AKT (pAKT) expression was significantly related to HER4 expression. Expression of each of these biomarkers was significantly related to longer EFS (P = 0.024 and 0.03, respectively). pERK expression was also a good prognostic factor regarding EFS and OS in TNBC (P = 0.002 and 0.006, respectively). We also identified a correlation between epidermal growth factor receptor positivity and insulin-like growth factor receptor type 1 positivity (P = 0.001). pERK and T-stage (1-3 versus >3) were independent good prognostic factors by multivariate analysis. CONCLUSIONS: We determined that tumors expressing pAKT or pERK are a good prognostic subtype in node-positive TNBC. Different targeted therapies may be necessary for TNBC that involves activation of PI3K/AKT or MAPK pathways.
BACKGROUND: Triple-negative breast cancer (TNBC) patients are a poor prognostic subgroup, and currently, there is no biomarker for targeted therapy. PATIENTS AND METHODS: Tissue samples were obtained from 75 TNBC patients with lymph-node metastases who had received adjuvant chemotherapy. We examined 11 biomarkers, including PIK3CA and AKT1mutation, with regard to event-free survival (EFS) and overall survival (OS) of patients. RESULTS: In the tumor tissues, phospho-AKT (pAKT) expression was significantly related to HER4 expression. Expression of each of these biomarkers was significantly related to longer EFS (P = 0.024 and 0.03, respectively). pERK expression was also a good prognostic factor regarding EFS and OS in TNBC (P = 0.002 and 0.006, respectively). We also identified a correlation between epidermal growth factor receptor positivity and insulin-like growth factor receptor type 1 positivity (P = 0.001). pERK and T-stage (1-3 versus >3) were independent good prognostic factors by multivariate analysis. CONCLUSIONS: We determined that tumors expressing pAKT or pERK are a good prognostic subtype in node-positive TNBC. Different targeted therapies may be necessary for TNBC that involves activation of PI3K/AKT or MAPK pathways.
Authors: Mercedes Herrera Juarez; Pablo Tolosa Ortega; Ana Sanchez de Torre; Eva Ciruelos Gil Journal: Breast Care (Basel) Date: 2020-06-05 Impact factor: 2.860
Authors: Paolo Cossu-Rocca; Sandra Orrù; Maria Rosaria Muroni; Francesca Sanges; Giovanni Sotgiu; Sara Ena; Giovanna Pira; Luciano Murgia; Alessandra Manca; Maria Gabriela Uras; Maria Giuseppina Sarobba; Silvana Urru; Maria Rosaria De Miglio Journal: PLoS One Date: 2015-11-05 Impact factor: 3.240