Literature DB >> 25008940

Spatial localization of the Ebola virus glycoprotein mucin-like domain determined by cryo-electron tomography.

Erin E H Tran1, James A Simmons2, Alberto Bartesaghi1, Charles J Shoemaker2, Elizabeth Nelson2, Judith M White2, Sriram Subramaniam3.   

Abstract

The Ebola virus glycoprotein mucin-like domain (MLD) is implicated in Ebola virus cell entry and immune evasion. Using cryo-electron tomography of Ebola virus-like particles, we determined a three-dimensional structure for the full-length glycoprotein in a near-native state and compared it to that of a glycoprotein lacking the MLD. Our results, which show that the MLD is located at the apex and the sides of each glycoprotein monomer, provide a structural template for analysis of MLD function.
Copyright © 2014, American Society for Microbiology. All Rights Reserved.

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Year:  2014        PMID： 25008940      PMCID： PMC4178867          DOI： 10.1128/JVI.00870-14

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


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