BACKGROUND: Magnesium deficiency is associated with poor physical performance, but no trials are available on how magnesium supplementation affects elderly people's physical performance. OBJECTIVE: The aim of our study was to investigate whether 12 wk of oral magnesium supplementation can improve physical performance in healthy elderly women. DESIGN: In a parallel-group, randomized controlled trial, 139 healthy women (mean ± SD age: 71.5 ± 5.2 y) attending a mild fitness program were randomly allocated to a treatment group (300 mg Mg/d; n = 62) or a control group (no placebo or intervention; n = 77) by using a computer-generated randomization sequence, and researchers were blinded to their grouping. After assessment at baseline and again after 12 wk, the primary outcome was a change in the Short Physical Performance Battery (SPPB); secondary outcomes were changes in peak torque isometric and isokinetic strength of the lower limbs and handgrip strength. RESULTS: A total of 124 participants allocated to the treatment (n = 53) or control (n = 71) group were considered in the final analysis. At baseline, the SPPB scores did not differ between the 2 groups. After 12 wk, the treated group had a significantly better total SPPB score (Δ = 0.41 ± 0.24 points; P = 0.03), chair stand times (Δ = -1.31 ± 0.33 s; P < 0.0001), and 4-m walking speeds (Δ = 0.14 ± 0.03 m/s; P = 0.006) than did the control group. These findings were more evident in participants with a magnesium dietary intake lower than the Recommended Dietary Allowance. No significant differences emerged for the secondary outcomes investigated, and no serious adverse effects were reported. CONCLUSIONS:Daily magnesium oxide supplementation for 12 wk seems to improve physical performance in healthy elderly women. These findings suggest a role for magnesium supplementation in preventing or delaying the age-related decline in physical performance.
RCT Entities:
BACKGROUND:Magnesium deficiency is associated with poor physical performance, but no trials are available on how magnesium supplementation affects elderly people's physical performance. OBJECTIVE: The aim of our study was to investigate whether 12 wk of oral magnesium supplementation can improve physical performance in healthy elderly women. DESIGN: In a parallel-group, randomized controlled trial, 139 healthy women (mean ± SD age: 71.5 ± 5.2 y) attending a mild fitness program were randomly allocated to a treatment group (300 mg Mg/d; n = 62) or a control group (no placebo or intervention; n = 77) by using a computer-generated randomization sequence, and researchers were blinded to their grouping. After assessment at baseline and again after 12 wk, the primary outcome was a change in the Short Physical Performance Battery (SPPB); secondary outcomes were changes in peak torque isometric and isokinetic strength of the lower limbs and handgrip strength. RESULTS: A total of 124 participants allocated to the treatment (n = 53) or control (n = 71) group were considered in the final analysis. At baseline, the SPPB scores did not differ between the 2 groups. After 12 wk, the treated group had a significantly better total SPPB score (Δ = 0.41 ± 0.24 points; P = 0.03), chair stand times (Δ = -1.31 ± 0.33 s; P < 0.0001), and 4-m walking speeds (Δ = 0.14 ± 0.03 m/s; P = 0.006) than did the control group. These findings were more evident in participants with a magnesium dietary intake lower than the Recommended Dietary Allowance. No significant differences emerged for the secondary outcomes investigated, and no serious adverse effects were reported. CONCLUSIONS: Daily magnesium oxide supplementation for 12 wk seems to improve physical performance in healthy elderly women. These findings suggest a role for magnesium supplementation in preventing or delaying the age-related decline in physical performance.
Authors: M Tieland; R Franssen; C Dullemeijer; C van Dronkelaar; H Kyung Kim; T Ispoglou; K Zhu; R L Prince; L J C van Loon; L C P G M de Groot Journal: J Nutr Health Aging Date: 2017 Impact factor: 4.075
Authors: N Veronese; C Trevisan; S Carraro; S Sarti; B M Zanforlini; M De Rui; A Coin; E Manzato; G Sergi Journal: Eur J Clin Nutr Date: 2016-06-01 Impact factor: 4.016
Authors: N Veronese; S Watutantrige-Fernando; C Luchini; M Solmi; G Sartore; G Sergi; E Manzato; M Barbagallo; S Maggi; B Stubbs Journal: Eur J Clin Nutr Date: 2016-08-17 Impact factor: 4.016
Authors: C Trevisan; N Veronese; L Berton; S Carraro; F Bolzetta; M De Rui; F Miotto; E M Inelmen; A Coin; E Perissinotto; E Manzato; G Sergi Journal: J Nutr Health Aging Date: 2017 Impact factor: 4.075
Authors: Charles James Steward; Yue Zhou; Gary Keane; Matthew David Cook; Yunyi Liu; Tom Cullen Journal: Eur J Appl Physiol Date: 2019-10-17 Impact factor: 3.078
Authors: Linda Berton; Giulia Bano; Sara Carraro; Nicola Veronese; Simona Pizzato; Francesco Bolzetta; Marina De Rui; Elena Valmorbida; Irene De Ronch; Egle Perissinotto; Alessandra Coin; Enzo Manzato; Giuseppe Sergi Journal: PLoS One Date: 2015-11-03 Impact factor: 3.240