Kathie-Ann Joseph1, Xuan Luu, Adam Mor. 1. Department of Surgery, Bellevue Hospital Center, NYU Langone School of Medicine, New York, NY, USA, Kathie-Ann.Joseph@nyumc.org.
Abstract
BACKGROUND: Granulomatous mastitis is an uncommon chronic inflammatory breast condition that is characterized by granulomatous inflammation. Granulomatous mastitis presents a challenging clinical scenario, because it can mimic carcinoma. The etiology and optimal treatment remain unclear. We report our experience with granulomatous mastitis patients who presented to our clinic within the past 2 years and describe their response to our treatment modalities. METHODS: Our clinic records were reviewed for the diagnosis of granulomatous mastitis. Charts were used to collect clinical data, patients were reinter viewed, and physicians completed detailed reports on their management of these cases. All cases were diagnosed with granulomatous mastitis based on histological findings and by ruling out other etiologies. RESULTS: Twenty-four patients were identified. The mean age was 34 years. Fifty-three percent of our patients emigrated from Mexico. Most patients were treated with prednisone and/or methotrexate with overall response rate greater than 80 %. Cases that failed to improve were treated with other modalities, including antituberculosis drugs. CONCLUSIONS: Granulomatous mastitis remains a difficult entity to diagnose and to treat. The clinical course of patients often is prolonged. Exclusion of other causes of granulomatous conditions is essential before initiating anti-inflammatory treatment.
BACKGROUND:Granulomatous mastitis is an uncommon chronic inflammatory breast condition that is characterized by granulomatous inflammation. Granulomatous mastitis presents a challenging clinical scenario, because it can mimic carcinoma. The etiology and optimal treatment remain unclear. We report our experience with granulomatous mastitispatients who presented to our clinic within the past 2 years and describe their response to our treatment modalities. METHODS: Our clinic records were reviewed for the diagnosis of granulomatous mastitis. Charts were used to collect clinical data, patients were reinter viewed, and physicians completed detailed reports on their management of these cases. All cases were diagnosed with granulomatous mastitis based on histological findings and by ruling out other etiologies. RESULTS: Twenty-four patients were identified. The mean age was 34 years. Fifty-three percent of our patients emigrated from Mexico. Most patients were treated with prednisone and/or methotrexate with overall response rate greater than 80 %. Cases that failed to improve were treated with other modalities, including antituberculosis drugs. CONCLUSIONS:Granulomatous mastitis remains a difficult entity to diagnose and to treat. The clinical course of patients often is prolonged. Exclusion of other causes of granulomatous conditions is essential before initiating anti-inflammatory treatment.
Authors: Osman Toktas; Can Konca; Didem Can Trabulus; Aykut Soyder; Hande Koksal; Hasan Karanlik; Ayfer Kamali Polat; Serdar Ozbas; Serdar Yormaz; Arda Isik; Efe Sezgin; Atilla Soran Journal: Breast Care (Basel) Date: 2020-06-30 Impact factor: 2.860
Authors: Marcia E Bouton; Lisa M Winton; Sonal G Gandhi; Lakshmi Jayaram; Prahladbhai N Patel; Patrick J O' Neill; Ian K Komenaka Journal: Int J Surg Case Rep Date: 2015-03-04