Literature DB >> 25006417

Perioperative pharmacological management of pulmonary hypertensive crisis during congenital heart surgery.

Nathan Brunner1, Vinicio A de Jesus Perez1, Alice Richter1, François Haddad2, André Denault3, Vanessa Rojas1, Ke Yuan1, Mark Orcholski1, Xiaobo Liao4.   

Abstract

Pulmonary hypertensive crisis is an important cause of morbidity and mortality in patients with pulmonary arterial hypertension secondary to congenital heart disease (PAH-CHD) who require cardiac surgery. At present, prevention and management of perioperative pulmonary hypertensive crisis is aimed at optimizing cardiopulmonary interactions by targeting prostacyclin, endothelin, and nitric oxide signaling pathways within the pulmonary circulation with various pharmacological agents. This review is aimed at familiarizing the practitioner with the current pharmacological treatment for dealing with perioperative pulmonary hypertensive crisis in PAH-CHD patients. Given the life-threatening complications associated with pulmonary hypertensive crisis, proper perioperative planning can help anticipate cardiopulmonary complications and optimize surgical outcomes in this patient population.

Entities:  

Keywords:  congenital heart diseases; perioperative pharmacological therapies; pulmonary arterial hypertension; pulmonary hypertensive crisis

Year:  2014        PMID： 25006417      PMCID： PMC4070760          DOI： 10.1086/674885

Source DB:  PubMed          Journal:  Pulm Circ        ISSN： 2045-8932            Impact factor:   3.017


  132 in total

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