| Literature DB >> 25006012 |
Yujun Sheng1, Xin Jin2, Jinhua Xu3, Jinping Gao4, Xiaoqing Du5, Dawei Duan5, Bing Li5, Jinhua Zhao5, Wenying Zhan5, Huayang Tang5, Xianfa Tang5, Yang Li5, Hui Cheng5, Xianbo Zuo5, Junpu Mei6, Fusheng Zhou5, Bo Liang5, Gang Chen5, Changbing Shen5, Hongzhou Cui5, Xiaoguang Zhang5, Change Zhang5, Wenjun Wang5, Xiaodong Zheng5, Xing Fan5, Zaixing Wang5, Fengli Xiao5, Yong Cui5, Yingrui Li6, Jun Wang7, Sen Yang5, Lei Xu8, Liangdan Sun5, Xuejun Zhang9.
Abstract
In a previous large-scale exome sequencing analysis for psoriasis, we discovered seven common and low-frequency missense variants within six genes with genome-wide significance. Here we describe an in-depth analysis of noncoding variants based on sequencing data (10,727 cases and 10,582 controls) with replication in an independent cohort of Han Chinese individuals consisting of 4,480 cases and 6,521 controls to identify additional psoriasis susceptibility loci. We confirmed four known psoriasis susceptibility loci (IL12B, IFIH1, ERAP1 and RNF114; 2.30 × 10(-20)≤P≤2.41 × 10(-7)) and identified three new susceptibility loci: 4q24 (NFKB1) at rs1020760 (P=2.19 × 10(-8)), 12p13.3 (CD27-LAG3) at rs758739 (P=4.08 × 10(-8)) and 17q12 (IKZF3) at rs10852936 (P=1.96 × 10(-8)). Two suggestive loci, 3p21.31 and 17q25, are also identified with P<1.00 × 10(-6). The results of this study increase the number of confirmed psoriasis risk loci and provide novel insight into the pathogenesis of psoriasis.Entities:
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Year: 2014 PMID： 25006012 DOI： 10.1038/ncomms5331
Source DB: PubMed Journal: Nat Commun ISSN： 2041-1723 Impact factor: 14.919