Literature DB >> 25005941

Anthocyanins from Eugenia brasiliensis edible fruits as potential therapeutics for COPD treatment.

Gema Flores1, Keyvan Dastmalchi2, Sturlainny Paulino2, Kathleen Whalen3, Abdoulaye J Dabo4, Kurt A Reynertson2, Robert F Foronjy4, Jeanine M D'Armiento4, Edward J Kennelly2.   

Abstract

Nine anthocyanins (1-9) from the edible fruits of Eugenia brasiliensis were identified by HPLC-PDA and LC-MS, and seven of these are described for the first time in this Brazilian fruit. Two of the major anthocyanins, delphinidin (8) and cyanidin (9), were studied for their inhibitory activity against chemokine interleukin-8 (IL-8) production before and after cigarette smoke extract (CSE) treatment of cells. In non-treated cells the amount of IL-8 was unchanged following treatment with cyanidin and delphinidin in concentrations 0.1-10 μM. Both delphinidin (8) and cyanidin (9) decreased the production of IL-8 in treated cells, at 1 and 10 μM, respectively. Delphinidin (8) demonstrated IL-8 inhibition in the CSE treated cells in a dose-dependent manner.
Copyright © 2012 Elsevier Ltd. All rights reserved.

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Year:  2012        PMID： 25005941      PMCID： PMC4096213          DOI： 10.1016/j.foodchem.2012.01.086

Source DB:  PubMed          Journal:  Food Chem        ISSN： 0308-8146            Impact factor:   7.514


  36 in total

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