INTRODUCTION: Though the lifetime risk of colorectal carcinoma (CRC) in general population is 5-6 %, it is uncommon in pediatric age group. Here, we are reporting our experience of CRC in the first decade of life. METHODS: From January 2010 to December 2013, seven patients with histopathologically confirmed colorectal carcinoma were treated in the Department of Pediatric Surgery, Chittagong Medical College and hospital. Age, sex, presenting symptoms, location of the primary tumor, serum CEA level, treatment modalities and outcomes were evaluated. RESULTS: There were four male and three female patients and age ranged from 6.5 to 10.5 years. Rectum (3 patients) and rectosigmoid (2 patients) were the most common primary sites. Serum carcinoembryonic antigen level was obtained in six patients and in only one patient the level was raised markedly (137 ng/ml). Two patients of familial adenomatous polyposis had localized disease and others presented in an advanced stage. Histopathologically, poorly differentiated adenocarcinoma was noted in five patients with one signet ring cell type and well differentiated in rest of the two patients. Only one patient was surviving at the last follow up. CONCLUSION: Advanced stage at diagnosis, aggressive histologic subtype and poor survival are the hallmarks of pediatric CRC.
INTRODUCTION: Though the lifetime risk of colorectal carcinoma (CRC) in general population is 5-6 %, it is uncommon in pediatric age group. Here, we are reporting our experience of CRC in the first decade of life. METHODS: From January 2010 to December 2013, seven patients with histopathologically confirmed colorectal carcinoma were treated in the Department of Pediatric Surgery, Chittagong Medical College and hospital. Age, sex, presenting symptoms, location of the primary tumor, serum CEA level, treatment modalities and outcomes were evaluated. RESULTS: There were four male and three female patients and age ranged from 6.5 to 10.5 years. Rectum (3 patients) and rectosigmoid (2 patients) were the most common primary sites. Serum carcinoembryonic antigen level was obtained in six patients and in only one patient the level was raised markedly (137 ng/ml). Two patients of familial adenomatous polyposis had localized disease and others presented in an advanced stage. Histopathologically, poorly differentiated adenocarcinoma was noted in five patients with one signet ring cell type and well differentiated in rest of the two patients. Only one patient was surviving at the last follow up. CONCLUSION: Advanced stage at diagnosis, aggressive histologic subtype and poor survival are the hallmarks of pediatric CRC.
Authors: Muhammet A Kaplan; Abdurrahman Isikdogan; Mahmut Gumus; Ulku Y Arslan; Caglayan Geredeli; Nuriye Ozdemir; Dogan Koca; Faysal Dane; Ali Suner; Emin T Elkiran; Mehmet Kucukoner; Mesut Seker; Kaan Helvaci; Tunc Guler; Dogan Uncu; Ali Inal; Ramazan Yildiz Journal: J Pediatr Hematol Oncol Date: 2013-03 Impact factor: 1.289
Authors: S Madajewicz; N Petrelli; Y M Rustum; J Campbell; L Herrera; A Mittelman; A Perry; P J Creaven Journal: Cancer Res Date: 1984-10 Impact factor: 12.701