Literature DB >> 25003719

Enhanced immune activation linked to endotoxemia in HIV-1 seronegative MSM.

Christine D Palmer, Julia Tomassilli, Michael Sirignano, Marisol Romero-Tejeda, Kelly B Arnold, Denise Che, Douglas A Lauffenburger, Stephanie Jost, Todd Allen, Kenneth H Mayer, Marcus Altfeld.   

Abstract

This study assessed cellular and soluble markers of immune activation in HIV-1 seronegative MSM. MSM immune profiles were characterized by an increased expression of CD57 on T cells and endotoxemia. Endotoxin presence was linked to recent high-risk exposure and associated with elevated cytokine levels and decreased CD4+/CD8+ T cell ratios. Taken together, these data show elevated levels of inflammation linked to periods of endotoxemia resulting in a significantly different immune phenotype in a subset of MSM at a high risk of HIV-1 acquisition.

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Year:  2014        PMID： 25003719      PMCID： PMC4460793          DOI： 10.1097/QAD.0000000000000386

Source DB:  PubMed          Journal:  AIDS        ISSN： 0269-9370            Impact factor:   4.177


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