| Literature DB >> 2500358 |
A Jurado1, J Carballido, H Griffel, H K Hochkeppel, G D Wetzel.
Abstract
Interferon-gamma (IFN-gamma) exerts a broad spectrum of activities which affect the responses of mature B-cells. It strongly inhibits B-cell activation, acts as a B-cell growth factor (BCGF), and also induces final differentiation to immunoglobulin (Ig) production. IFN-gamma is deeply involved in the differential control of isotype expression, as it enhances IgG2a production and suppresses both IgG1 and IgE production. Although it is now possible to draw a general scheme of the effects of IFN-gamma on B-cells, a number of paradoxical results still exist in the field. In this manuscript, different experimental systems are analyzed in an attempt to explain these apparent paradoxes.Entities:
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Year: 1989 PMID： 2500358 DOI： 10.1007/bf01990501
Source DB: PubMed Journal: Experientia ISSN： 0014-4754