Alexander J Szalai1, Scott R Barnum2, Theresa N Ramos3. 1. Department of Medicine, The University of Alabama at Birmingham, Birmingham, Alabama 35294, USA. 2. Department of Microbiology, The University of Alabama at Birmingham, Birmingham, Alabama 35294, USA sbarnum@uab.edu. 3. Department of Microbiology, The University of Alabama at Birmingham, Birmingham, Alabama 35294, USA.
Abstract
BACKGROUND: C-reactive protein (CRP) level correlates with parasitemia and severity of malaria, but whether this reflects causality remains unknown. METHODS: Using CRP-transgenic and CRP-deficient mice we compared the onset and severity of experimental cerebral malaria (ECM) induced by Plasmodium berghei ANKA (PbA). RESULTS: CRP-deficient mice were most resistant to ECM. CONCLUSIONS: CRP might contribute to the development of cerebral malaria, rather than protect against it.
BACKGROUND:C-reactive protein (CRP) level correlates with parasitemia and severity of malaria, but whether this reflects causality remains unknown. METHODS: Using CRP-transgenic and CRP-deficient mice we compared the onset and severity of experimental cerebral malaria (ECM) induced by Plasmodium berghei ANKA (PbA). RESULTS:CRP-deficient mice were most resistant to ECM. CONCLUSIONS:CRP might contribute to the development of cerebral malaria, rather than protect against it.
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