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Literature DB >> 25002025

Optimizing IGF-I for skeletal muscle therapeutics.

Anastassios Philippou¹, Elisabeth R Barton².

Abstract

It is virtually undisputed that IGF-I promotes cell growth and survival. However, the presence of several IGF-I isoforms, vast numbers of intracellular signaling components, and multiple receptors results in a complex and highly regulated system by which IGF-I actions are mediated. IGF-I has long been recognized as one of the critical factors for coordinating muscle growth, enhancing muscle repair, and increasing muscle mass and strength. How to optimize this panoply of pathways to drive anabolic processes in muscle as opposed to aberrant growth in other tissues is an area that deserves focus. This review will address how advances in the bioavailability, potency, and tissue response of IGF-I can provide new potential directions for skeletal muscle therapeutics.

Entities: Chemical Disease Gene Mutation Species

Keywords: Anabolism; Hypertrophy; Isoforms; Post-translational processing; Satellite cells

Mesh：

Substances：

Year: 2014 PMID： 25002025 PMCID： PMC4665094 DOI： 10.1016/j.ghir.2014.06.003

Source DB: PubMed Journal: Growth Horm IGF Res ISSN： 1096-6374 Impact factor: 2.372

107 in total

Review 1. Insulin-like growth factors (IGFs), IGF receptors, and IGF-binding proteins: roles in skeletal muscle growth and differentiation.

Authors: Cunming Duan; Hongxia Ren; Shan Gao
Journal: Gen Comp Endocrinol Date: 2010-04-18 Impact factor: 2.822

2. Viral expression of insulin-like growth factor-I isoforms promotes different responses in skeletal muscle.

Authors: Elisabeth R Barton
Journal: J Appl Physiol (1985) Date: 2006-01-26

3. Therapeutic potential of PEGylated insulin-like growth factor I for skeletal muscle disease evaluated in two murine models of muscular dystrophy.

Authors: Stefan M Gehrig; Chris van der Poel; Andreas Hoeflich; Timur Naim; Gordon S Lynch; Friedrich Metzger
Journal: Growth Horm IGF Res Date: 2012-03-15 Impact factor: 2.372

4. Impact of viral-mediated IGF-I gene transfer on skeletal muscle following cast immobilization.

Authors: Jennifer E Stevens-Lapsley; Fan Ye; Min Liu; Stephen E Borst; Christine Conover; Kevin E Yarasheski; Glenn A Walter; H Lee Sweeney; Krista Vandenborne
Journal: Am J Physiol Endocrinol Metab Date: 2010-08-24 Impact factor: 4.310

5. Is functional hypertrophy and specific force coupled with the addition of myonuclei at the single muscle fiber level?

Authors: Rizwan Qaisar; Guillaume Renaud; Kevin Morine; Elisabeth R Barton; H Lee Sweeney; Lars Larsson
Journal: FASEB J Date: 2011-11-28 Impact factor: 5.191

6. HGF/SF is present in normal adult skeletal muscle and is capable of activating satellite cells.

Authors: R Tatsumi; J E Anderson; C J Nevoret; O Halevy; R E Allen
Journal: Dev Biol Date: 1998-02-01 Impact factor: 3.582

7. Intramuscular administration of PEGylated IGF-I improves skeletal muscle regeneration after myotoxic injury.

Authors: Karen J B Martins; Stefan M Gehrig; Timur Naim; Stefanie Saenger; Dale Baum; Friedrich Metzger; Gordon S Lynch
Journal: Growth Horm IGF Res Date: 2013-04-19 Impact factor: 2.372

8. IGF-I gene transfer by electroporation promotes regeneration in a muscle injury model.

Authors: T Takahashi; K Ishida; K Itoh; Y Konishi; K-I Yagyu; A Tominaga; J-I Miyazaki; H Yamamoto
Journal: Gene Ther Date: 2003-04 Impact factor: 5.250

9. Myogenic vector expression of insulin-like growth factor I stimulates muscle cell differentiation and myofiber hypertrophy in transgenic mice.

Authors: M E Coleman; F DeMayo; K C Yin; H M Lee; R Geske; C Montgomery; R J Schwartz
Journal: J Biol Chem Date: 1995-05-19 Impact factor: 5.157

10. E-peptides control bioavailability of IGF-1.

Authors: Marianne Smedegaard Hede; Ekaterina Salimova; Agnieszka Piszczek; Emarald Perlas; Nadine Winn; Tommaso Nastasi; Nadia Rosenthal
Journal: PLoS One Date: 2012-12-10 Impact factor: 3.240

22 in total

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Authors: Athanasios Moustogiannis; Anastassios Philippou; Evangelos Zevolis; Orjona Taso; Antonios Chatzigeorgiou; Michael Koutsilieris
Journal: In Vivo Date: 2020 Jul-Aug Impact factor: 2.155

Review 2. Vaccination via Chloroplast Genetics: Affordable Protein Drugs for the Prevention and Treatment of Inherited or Infectious Human Diseases.

Authors: Henry Daniell; Hui-Ting Chan; Elise K Pasoreck
Journal: Annu Rev Genet Date: 2016-10-21 Impact factor: 16.830

Review 3. Pharmacological targeting of age-related changes in skeletal muscle tissue.

Authors: Aurel B Leuchtmann; Christoph Handschin
Journal: Pharmacol Res Date: 2019-03-04 Impact factor: 7.658

4. CRISPR-Cas9-induced IGF1 gene activation as a tool for enhancing muscle differentiation via multiple isoform expression.

Authors: Matthew J Roberston; Suchi Raghunathan; Vladimir N Potaman; Fan Zhang; M David Stewart; Bradley K McConnell; Robert J Schwartz
Journal: FASEB J Date: 2019-11-25 Impact factor: 5.191