BACKGROUND: Numerous studies are ongoing in the fields of nanotoxicology and exposure science; however, gaps remain in identifying and evaluating potential exposures from skin contact with engineered nanoparticles in occupational settings. OBJECTIVES: The aim of this study was to identify potential cutaneous exposure scenarios at a workplace using engineered nanoparticles (alumina, ceria, amorphous silica) and evaluate the presence of these materials on workplace surfaces. METHODS: Process review, workplace observations, and preliminary surface sampling were conducted using microvacuum and wipe sample collection methods and transmission electron microscopy with elemental analysis. RESULTS: Exposure scenarios were identified with potential for incidental contact. Nanoparticles of silica or silica and/or alumina agglomerates (or aggregates) were identified in surface samples from work areas where engineered nanoparticles were used or handled. CONCLUSIONS: Additional data are needed to evaluate occupational exposures from skin contact with engineered nanoparticles; precautionary measures should be used to minimize potential cutaneous exposures in the workplace.
BACKGROUND: Numerous studies are ongoing in the fields of nanotoxicology and exposure science; however, gaps remain in identifying and evaluating potential exposures from skin contact with engineered nanoparticles in occupational settings. OBJECTIVES: The aim of this study was to identify potential cutaneous exposure scenarios at a workplace using engineered nanoparticles (alumina, ceria, amorphous silica) and evaluate the presence of these materials on workplace surfaces. METHODS: Process review, workplace observations, and preliminary surface sampling were conducted using microvacuum and wipe sample collection methods and transmission electron microscopy with elemental analysis. RESULTS: Exposure scenarios were identified with potential for incidental contact. Nanoparticles of silica or silica and/or alumina agglomerates (or aggregates) were identified in surface samples from work areas where engineered nanoparticles were used or handled. CONCLUSIONS: Additional data are needed to evaluate occupational exposures from skin contact with engineered nanoparticles; precautionary measures should be used to minimize potential cutaneous exposures in the workplace.
Authors: Brian Gulson; Herbert Wong; Michael Korsch; Laura Gomez; Philip Casey; Maxine McCall; Malcolm McCulloch; Julie Trotter; Jenny Stauber; Gavin Greenoak Journal: Sci Total Environ Date: 2012-02-07 Impact factor: 7.963
Authors: Sheree E Cross; Brian Innes; Michael S Roberts; Takuya Tsuzuki; Terry A Robertson; Paul McCormick Journal: Skin Pharmacol Physiol Date: 2007-01-17 Impact factor: 3.479
Authors: Paul J A Borm; David Robbins; Stephan Haubold; Thomas Kuhlbusch; Heinz Fissan; Ken Donaldson; Roel Schins; Vicki Stone; Wolfgang Kreyling; Jurgen Lademann; Jean Krutmann; David Warheit; Eva Oberdorster Journal: Part Fibre Toxicol Date: 2006-08-14 Impact factor: 9.400
Authors: P A Schulte; G Roth; L L Hodson; V Murashov; M D Hoover; R Zumwalde; E D Kuempel; C L Geraci; A B Stefaniak; V Castranova; J Howard Journal: J Nanopart Res Date: 2016-06-14 Impact factor: 2.253