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Literature DB >> 2500011

The effects of TMB-8 on the shape changes of vascular endothelial cells resulting from exposure to various inflammatory agents.

Abstract

Pre-treatment of the endothelial cells lining the guinea pig inferior vena cava with 8-(diethylamino)octyl 3,4,5-trimethoxybenzoate (TMB-8) (10 microM) in vitro significantly reduced the shape changes resulting from subsequent exposure to platelet activating factor (PAF) (0.1 microM), calcium ionophore A23187 (10 microM), histamine (300 microM), bradykinin (2 microM), prostaglandin E2 (PGE2) (30 microM), or leukotrienes (LT) C4, D4 or E4 (1 microM). Since TMB-8 is an intracellular calcium antagonist, this provides evidence to support the suggestion that these inflammatory agents increase the concentration of intracellular calcium which brings about a contraction of the actin-myosin complex resulting in endothelial cell shape changes, and the formation of interendothelial cell gaps.

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Year: 1989 PMID： 2500011 DOI： 10.1007/bf01967303

Source DB: PubMed Journal: Agents Actions ISSN： 0065-4299

27 in total

4. Human endothelial cells are target for platelet-activating factor. I. Platelet-activating factor induces changes in cytoskeleton structures.

Authors: F Bussolino; G Camussi; M Aglietta; P Braquet; A Bosia; G Pescarmona; F Sanavio; N D'Urso; P C Marchisio
Journal: J Immunol Date: 1987-10-01 Impact factor: 5.422

5. On the mechanism of vascular leakage caused by histaminetype mediators. A microscopic study in vivo.

Authors: G Majno; V Gilmore; M Leventhal
Journal: Circ Res Date: 1967-12 Impact factor: 17.367

6. Calcium dependency of prostaglandin E2 production in rat glomerular mesangial cells. Evidence that protein kinase C modulates the Ca2+-dependent activation of phospholipase A2.

Authors: J V Bonventre; M Swidler
Journal: J Clin Invest Date: 1988-07 Impact factor: 14.808

7. Effects of bradykinin and angiotensin II on intracellular Ca2+ dynamics in endothelial cells.

Authors: R Morgan-Boyd; J M Stewart; R J Vavrek; A Hassid
Journal: Am J Physiol Date: 1987-10

8. Pharmacological evaluation of a new Ca2+ antagonist, 8-(N,N-diethylamino)-octyl-3,4,5-trimethoxybenzoate hydrochloride (TMB-8): studies in smooth muscles.

Authors: M H Malagodi; C Y Chiou
Journal: Eur J Pharmacol Date: 1974-06 Impact factor: 4.432

9. Mechanism of inhibitory action of TMB-8 [8-(NN-diethylamino)octyl-3,4,5-trimethoxybenzoate] on aldosterone secretion in adrenal glomerulosa cells.

Authors: I Kojima; K Kojima; H Rasmussen
Journal: Biochem J Date: 1985-11-15 Impact factor: 3.857

3. Modification by some antagonists of the shape changes of venous endothelial cells in response to inflammatory agents in vitro.

Authors: A M Northover
Journal: Agents Actions Date: 1990-03

4. Negative feedback neuroendocrine control of inflammatory response in the rat is dependent on the sympathetic postganglionic neuron.

Authors: P G Green; W Jänig; J D Levine
Journal: J Neurosci Date: 1997-05-01 Impact factor: 6.167

5. Possible bi-directional link between ET(A) receptors and protein kinase C in rat blood vessels.

Authors: A M Northover; B J Northover
Journal: Mediators Inflamm Date: 1995 Impact factor: 4.711

5 in total

The effects of TMB-8 on the shape changes of vascular endothelial cells resulting from exposure to various inflammatory agents.

1. Relationship between cellular calcium and prostaglandin synthesis in cultured vascular smooth muscle cells.

2. Microvascular permeability increase in rat skin: inhibition by flunarizine, a Ca2+ entry blocker.

3. Platelet activating factors alters calcium homeostasis in cultured vascular endothelial cells.