Literature DB >> 24999244

Effects of exercise in experimental autoimmune encephalomyelitis (an animal model of multiple sclerosis).

Rachel E Klaren1, Robert W Motl2, Jeffrey A Woods1, Stephen D Miller3.   

Abstract

Exercise training has improved many outcomes in "clinical" research involving persons with multiple sclerosis (MS), but there is limited understanding of the underlying "basic" pathophysiological mechanisms. The animal model of MS, experimental autoimmune encephalomyelitis (EAE), seems ideal for examining the effects of exercise training on MS-disease pathophysiology. EAE is an autoimmune T-helper cell-mediated disease characterized by T-cell and monocyte infiltration and inflammation in the CNS. To that end, this paper briefly describes common models of EAE, reviews existing research on exercise and EAE, and then identifies future research directions for understanding the consequences of exercise training using EAE.
Copyright © 2014 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Exercise; Experimental autoimmune encephalomyelitis; Multiple sclerosis

Mesh：

Year:  2014        PMID： 24999244      PMCID： PMC4404150          DOI： 10.1016/j.jneuroim.2014.06.014

Source DB:  PubMed          Journal:  J Neuroimmunol        ISSN： 0165-5728            Impact factor:   3.478


  57 in total

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Authors:  Elliot M Frohman; Michael K Racke; Cedric S Raine
Journal:  N Engl J Med       Date:  2006-03-02       Impact factor: 91.245

2.  Effect of exercise training on walking mobility in multiple sclerosis: a meta-analysis.

Authors:  Erin M Snook; Robert W Motl
Journal:  Neurorehabil Neural Repair       Date:  2008-10-23       Impact factor: 3.919

Review 3.  The experimental autoimmune encephalomyelitis (EAE) model of MS: utility for understanding disease pathophysiology and treatment.

Authors:  Andrew P Robinson; Christopher T Harp; Avertano Noronha; Stephen D Miller
Journal:  Handb Clin Neurol       Date:  2014

4.  Differential brain and spinal cord cytokine and BDNF levels in experimental autoimmune encephalomyelitis are modulated by prior and regular exercise.

Authors:  Danielle Bernardes; Onésia Cristina Oliveira-Lima; Thiago Vitarelli da Silva; Camila Cristina Fraga Faraco; Hércules Ribeiro Leite; Maria Aparecida Juliano; Daniel Moreira dos Santos; John R Bethea; Roberta Brambilla; Jacqueline M Orian; Rosa Maria Esteves Arantes; Juliana Carvalho-Tavares
Journal:  J Neuroimmunol       Date:  2013-09-01       Impact factor: 3.478

5.  Exercise attenuates the clinical, synaptic and dendritic abnormalities of experimental autoimmune encephalomyelitis.

Authors:  Silvia Rossi; Roberto Furlan; Valentina De Chiara; Alessandra Musella; Temistocle Lo Giudice; Giorgia Mataluni; Francesca Cavasinni; Cristina Cantarella; Giorgio Bernardi; Luca Muzio; Alessandro Martorana; Gianvito Martino; Diego Centonze
Journal:  Neurobiol Dis       Date:  2009-07-08       Impact factor: 5.996

Review 6.  Brain-derived neurotrophic factor in neuroimmunology: lessons learned from multiple sclerosis patients and experimental autoimmune encephalomyelitis models.

Authors:  Fred Lühder; Ralf Gold; Alexander Flügel; Ralf A Linker
Journal:  Arch Immunol Ther Exp (Warsz)       Date:  2013-01-03       Impact factor: 4.291

7.  Voluntary wheel running, but not a diet containing (-)-epigallocatechin-3-gallate and β-alanine, improves learning, memory and hippocampal neurogenesis in aged mice.

Authors:  Trisha E Gibbons; Brandt D Pence; Geraldine Petr; Jessica M Ossyra; Houston C Mach; Tushar K Bhattacharya; Samuel Perez; Stephen A Martin; Robert H McCusker; Keith W Kelley; Justin S Rhodes; Rodney W Johnson; Jeffrey A Woods
Journal:  Behav Brain Res       Date:  2014-07-05       Impact factor: 3.332

Review 8.  Exercise: a behavioral intervention to enhance brain health and plasticity.

Authors:  Carl W Cotman; Nicole C Berchtold
Journal:  Trends Neurosci       Date:  2002-06       Impact factor: 13.837

9.  Enlargement of cerebral ventricles as an early indicator of encephalomyelitis.

Authors:  Stefano Lepore; Helmar Waiczies; Jan Hentschel; Yiyi Ji; Julia Skodowski; Andreas Pohlmann; Jason M Millward; Friedemann Paul; Jens Wuerfel; Thoralf Niendorf; Sonia Waiczies
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10.  A biodegradable nanoparticle platform for the induction of antigen-specific immune tolerance for treatment of autoimmune disease.

Authors:  Zoe Hunter; Derrick P McCarthy; Woon Teck Yap; Christopher T Harp; Daniel R Getts; Lonnie D Shea; Stephen D Miller
Journal:  ACS Nano       Date:  2014-02-27       Impact factor: 15.881
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  11 in total

1.  Take the monkey and run.

Authors:  Kimberley A Phillips; M Karen Hambright; Kelly Hewes; Brian M Schilder; Corinna N Ross; Suzette D Tardif
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2.  Combined upper limb and breathing exercise programme for pain management in ambulatory and non-ambulatory multiple sclerosis individuals: part II analyses from feasibility study.

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Journal:  Neurol Sci       Date:  2019-08-17       Impact factor: 3.307

Review 3.  Exercise in the management of persons with multiple sclerosis.

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Journal:  Ther Adv Neurol Disord       Date:  2015-05       Impact factor: 6.570

4.  Characterizing Relationships Between Cognitive, Mental, and Physical Health and Physical Activity Levels in Persons With Multiple Sclerosis.

Authors:  Emily E Tyszka; Nina Bozinov; Farren B S Briggs
Journal:  Int J MS Care       Date:  2022-09-08

5.  Physical Exercise Attenuates Experimental Autoimmune Encephalomyelitis by Inhibiting Peripheral Immune Response and Blood-Brain Barrier Disruption.

Authors:  Priscila S Souza; Elaine D Gonçalves; Giulia S Pedroso; Hemelin R Farias; Stella C Junqueira; Rodrigo Marcon; Talita Tuon; Maíra Cola; Paulo C L Silveira; Adair R Santos; João B Calixto; Cláudio T Souza; Ricardo A de Pinho; Rafael C Dutra
Journal:  Mol Neurobiol       Date:  2016-07-22       Impact factor: 5.590

Review 6.  Benefits of Exercise Training in Multiple Sclerosis.

Authors:  Robert W Motl; Brian M Sandroff
Journal:  Curr Neurol Neurosci Rep       Date:  2015-09       Impact factor: 5.081

Review 7.  Mesenchymal Stem Cells of Dental Origin-Their Potential for Antiinflammatory and Regenerative Actions in Brain and Gut Damage.

Authors:  Anna Földes; Kristóf Kádár; Beáta Kerémi; Ákos Zsembery; Klára Gyires; Zoltán S Zádori; Gábor Varga
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8.  Aerobic Exercise Induces Functional and Structural Reorganization of CNS Networks in Multiple Sclerosis: A Randomized Controlled Trial.

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Review 9.  Immunomodulatory Effects of Exercise in Experimental Multiple Sclerosis.

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Journal:  Front Immunol       Date:  2019-09-13       Impact factor: 7.561

10.  Predictors of exercise participation in ambulatory and non-ambulatory older people with multiple sclerosis.

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Journal:  PeerJ       Date:  2015-08-06       Impact factor: 2.984
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