Yu-Mei Jiang1, Guang Li, Bao-Cun Sun, Xiu-Lan Zhao, Zhong-Kai Zhou. 1. Key Laboratory of Food Nutrition and Safety Ministry of Education, Tianjin University of Science and Technology, Tianjin International Joint Academy of Biomedicine, Tianjin, China E-mail : me1991@163.com.
Abstract
BACKGROUND: Recent reports have shown that C-X-C chemokine receptor 4 (CXCR4) plays an important role in metastasis. Despite a clear understanding of the protein's structure and properties, its functional role remains elusive. We conducted the present study to evaluate the expressions of CXCR4 in pancreatic cancer, and to investigate its relationship with clinicopathological parameters, especially perineural invasion(PNI). MATERIALS AND METHODS: The association between CXCR4 expression and perineural invasion was determined by immunohistochemistry in pancreatic cancer patients (n=51). RESULTS: CXCR4 expression was correlated with the existence of PNI and the type of PNI (p=0.042, p=0.040). TIMP-2 expression was also correlated with the existence, the pathway and degree of PNI (p=0.000, p=0.006, p=0.000). CONCLUSIONS: Our results suggest an association between PNI and expression of CXCR4 and TIMP-2 in pancreatic cancer. CXCR4 may promote the occurrence of PNI in pancreatic cancer cells by decreasing the inhibition of TIMPs on MMP.
BACKGROUND: Recent reports have shown that C-X-C chemokine receptor 4 (CXCR4) plays an important role in metastasis. Despite a clear understanding of the protein's structure and properties, its functional role remains elusive. We conducted the present study to evaluate the expressions of CXCR4 in pancreatic cancer, and to investigate its relationship with clinicopathological parameters, especially perineural invasion(PNI). MATERIALS AND METHODS: The association between CXCR4 expression and perineural invasion was determined by immunohistochemistry in pancreatic cancerpatients (n=51). RESULTS:CXCR4 expression was correlated with the existence of PNI and the type of PNI (p=0.042, p=0.040). TIMP-2 expression was also correlated with the existence, the pathway and degree of PNI (p=0.000, p=0.006, p=0.000). CONCLUSIONS: Our results suggest an association between PNI and expression of CXCR4 and TIMP-2 in pancreatic cancer. CXCR4 may promote the occurrence of PNI in pancreatic cancer cells by decreasing the inhibition of TIMPs on MMP.
Authors: Vincent Bernard; Alexander Semaan; Jonathan Huang; F Anthony San Lucas; Feven C Mulu; Bret M Stephens; Paola A Guerrero; Yanqing Huang; Jun Zhao; Nabiollah Kamyabi; Subrata Sen; Paul A Scheet; Cullen M Taniguchi; Michael P Kim; Ching-Wei Tzeng; Matthew H Katz; Aatur D Singhi; Anirban Maitra; Hector A Alvarez Journal: Clin Cancer Res Date: 2018-11-01 Impact factor: 12.531