| Literature DB >> 24998377 |
Mohamed Moumou1, Abderrahman El Bouakher2, Hassan Allouchi3, Ahmed El Hakmaoui1, Ahmed Benharref4, Véronique Mathieu5, Gérald Guillaumet6, Mohamed Akssira7.
Abstract
A series of 9α-hydroxyamino-parthenolides 3-10, 9β-hydroxyamino-parthenolides 11-13 and 9α-hydroxy-1β,10α-epoxyamino-parthenolides 15-19 were efficiently synthesized starting from 9α-hydroxyparthenolide 1 and 9β-hydroxyparthenolide 2, which were isolated from Anvillea radiata. Compounds 1-13 and 15-19 were evaluated for their in vitro anticancer activity by the MTT colorimetric assay against one murine and six human cancer cell lines. This work provides new details about the structural requisites for anticancer activity.Entities:
Keywords: 9-Hydroxyamino-parthenolides; 9-Hydroxyparthenolides; 9α-Hydroxy-1β,10α-epoxyamino-parthenolides; 9α-Hydroxy-1β,10α-epoxyparthenolides; Anticancer activity
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Year: 2014 PMID： 24998377 DOI： 10.1016/j.bmcl.2014.06.019
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823