BACKGROUND: SYNTAX score II (SSII) provides individualized estimates of 4-year mortality after coronary artery bypass grafting (CABG) and percutaneous coronary intervention (PCI) in order to facilitate decision-making between these revascularization methods. The purpose of the present study was to assess SSII in a real-world multicenter registry with distinct regional and epidemiological characteristics. METHODS AND RESULTS: Long-term mortality was analyzed in 3,896 patients undergoing PCI (n=2,190) or CABG (n=1,796) from the Coronary REvascularization Demonstrating Outcome Study in Kyoto (CREDO-Kyoto) PCI/CABG registry cohort-2. SSII discriminated well in both CABG and PCI patient groups (concordance index [c-index], 0.70; 95% CI: 0.68-0.72; and 0.75, 95% CI: 0.72-0.78) surpassing anatomical SYNTAX score (SS; c-index, 0.50; 95% CI: 0.47-0.53; and 0.59, 95% CI: 0.57-0.61). SSII had the best discriminative ability to separate low-, medium- and high-risk tertiles, and calibration plots showed good predictive performance for CABG and PCI groups. Use of anatomical SS as a reference improved the overall reclassification provided by SSII, with a net reclassification index of 0.5 (P<0.01). CONCLUSIONS: SSII has robust prognostic accuracy, both in CABG and in PCI patient groups and, compared with the anatomical SS alone, was more accurate in stratifying patients for late mortality in a real-world complex coronary artery disease Eastern population.
BACKGROUND: SYNTAX score II (SSII) provides individualized estimates of 4-year mortality after coronary artery bypass grafting (CABG) and percutaneous coronary intervention (PCI) in order to facilitate decision-making between these revascularization methods. The purpose of the present study was to assess SSII in a real-world multicenter registry with distinct regional and epidemiological characteristics. METHODS AND RESULTS: Long-term mortality was analyzed in 3,896 patients undergoing PCI (n=2,190) or CABG (n=1,796) from the Coronary REvascularization Demonstrating Outcome Study in Kyoto (CREDO-Kyoto) PCI/CABG registry cohort-2. SSII discriminated well in both CABG and PCI patient groups (concordance index [c-index], 0.70; 95% CI: 0.68-0.72; and 0.75, 95% CI: 0.72-0.78) surpassing anatomical SYNTAX score (SS; c-index, 0.50; 95% CI: 0.47-0.53; and 0.59, 95% CI: 0.57-0.61). SSII had the best discriminative ability to separate low-, medium- and high-risk tertiles, and calibration plots showed good predictive performance for CABG and PCI groups. Use of anatomical SS as a reference improved the overall reclassification provided by SSII, with a net reclassification index of 0.5 (P<0.01). CONCLUSIONS: SSII has robust prognostic accuracy, both in CABG and in PCI patient groups and, compared with the anatomical SS alone, was more accurate in stratifying patients for late mortality in a real-world complex coronary artery disease Eastern population.
Authors: Metin Çağdaş; Süleyman Karakoyun; Mahmut Yesin; İbrahim Rencüzoğulları; Yavuz Karabağ; Mahmut Uluganyan; Mustafa Ozan Gürsoy; İnanç Artaç; Doğan İliş; Eray Atalay; Öznur Sadioğlu Çağdaş Journal: Acta Cardiol Sin Date: 2018-01 Impact factor: 2.672
Authors: Maxime M Vroegindewey; Anne-Sophie Schuurman; Rohit M Oemrawsingh; Robert-Jan van Geuns; Isabella Kardys; Jurgen Ligthart; Joost Daemen; Eric Boersma; Patrick W Serruys; K Martijn Akkerhuis Journal: PLoS One Date: 2018-07-02 Impact factor: 3.240
Authors: Slayman Obeid; Antonio H Frangieh; Lorenz Räber; Nooraldaem Yousif; Thomas Gilhofer; Kyohei Yamaji; Milosz Jaguszewski; Soheila Aghlmandi; James Adams; Yannik Bockhorn; Christian Templin; Barbara E Stähli; Peter Jüni; Nicolas Rodondi; François Mach; Marco Roffi; Stephan Windecker; Willibald Maier; Fabian Nietlispach; Christian M Matter; Roland Klingenberg; Thomas F Lüscher Journal: Cardiol Res Pract Date: 2018-09-25 Impact factor: 1.866