Literature DB >> 2499825

Preliminary experience with topical phenytoin in wound healing in a war zone.

S G el Zayat.   

Abstract

Because of evidence that topical phenytoin (PHT) can promote wound healing, we undertook pilot clinical trials to evaluate its effectiveness in treating decubitus ulcers that resulted from war-related wounds at Basrah Teaching Hospital, Basrah, Iraq. Prompt pain relief, decreased wound exudate and bacterial contamination, enhanced granulation tissue formation, and more rapid healing characterized the PHT group. Fifteen PHT-treated decubitus ulcer patients healed in 1-3 weeks (one graft) versus 6-8 weeks (five grafts) in the control group. In addition, 20 patients with missile wounds were treated with PHT in an open trial. Further trials of PHT in war-related wounds are indicated.

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Year:  1989        PMID： 2499825

Source DB:  PubMed          Journal:  Mil Med        ISSN： 0026-4075            Impact factor:   1.437


  8 in total

1.  Two percent topical phenytoin sodium solution in treating pyoderma gangrenosum: a cohort study.

Authors:  Hewa Fonsekage Sanjeewani Fonseka; Sandeepa Madhujith Bandara Ekanayake; Manel Dissanayake
Journal:  Int Wound J       Date:  2010-08-17       Impact factor: 3.315

Review 2.  Dressings and topical agents for treating pressure ulcers.

Authors:  Maggie J Westby; Jo C Dumville; Marta O Soares; Nikki Stubbs; Gill Norman
Journal:  Cochrane Database Syst Rev       Date:  2017-06-22

3.  Topical Phenytoin Application in Grade I and II Diabetic Foot Ulcers: A Prospective Study.

Authors:  Vijaya Patil; Rashmi Patil; P L Kariholu; L S Patil; Praveeen Shahapur
Journal:  J Clin Diagn Res       Date:  2013-10-05

4.  Outcomes of topical phenytoin in the management of traumatic wounds.

Authors:  C Shyam Kumar; Nagashree Vasudeva; D Venkateswara Rao; Ch R S Ayyappa Naidu
Journal:  J Clin Orthop Trauma       Date:  2020-12-01

5.  Evaluation of wound healing effect of topical phenytoin on excisional wound in albino rats.

Authors:  Aa Hasamnis; Bk Mohanty; S Patil
Journal:  J Young Pharm       Date:  2010-01

6.  Phenytoin silver: a new nanocompound for promoting dermal wound healing via comprehensive pharmacological action.

Authors:  Xiao-Yu Ai; Hui-Juan Liu; Cheng Lu; Cai-Li Liang; Yan Sun; Shuang Chen; Bo Sun; Yang Li; Yan-Rong Liu; Qiang Zhang; Xue-Qiang Liu; Ting Xiao; Xue-Shuang Jing; Tao Sun; Hong-Gang Zhou; Cheng Yang
Journal:  Theranostics       Date:  2017-01-05       Impact factor: 11.556

7.  A Comparative Study on Therapeutic Efficacy of Autologous Platelet Rich Fibrin Matrix Versus Zinc Oxide And Phenytoin Paste in Non Healing Ulcers.

Authors:  Akanksha Singh; Yatendra S Chahar; Shaiphali Chhabra
Journal:  Indian J Dermatol       Date:  2021 Nov-Dec       Impact factor: 1.494

Review 8.  Topical phenytoin for treating pressure ulcers.

Authors:  Xiang Yong Hao; Hong Ling Li; He Su; Hui Cai; Tian Kang Guo; Ruifeng Liu; Lei Jiang; Yan Fei Shen
Journal:  Cochrane Database Syst Rev       Date:  2017-02-22
  8 in total

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