Elisa Cinotti1, Jean Luc Perrot2, Nelly Campolmi3, Bruno Labeille2, Marine Espinasse3, Damien Grivet3, Gilles Thuret4, Philippe Gain3, Catherine Douchet5, Fabien Forest5, Maher Haouas6, Frédéric Cambazard2. 1. Department of Dermatology, University Hospital of St-Etienne, Saint-Etienne, France. Electronic address: elisacinotti@gmail.com. 2. Department of Dermatology, University Hospital of St-Etienne, Saint-Etienne, France. 3. Department of Ophthalmology, University Hospital of St-Etienne, Saint-Etienne, France; Laboratory Biology, Engineering and Imaging of Corneal Graft, Jean Monnet University, Saint-Etienne, France. 4. Department of Ophthalmology, University Hospital of St-Etienne, Saint-Etienne, France; Laboratory Biology, Engineering and Imaging of Corneal Graft, Jean Monnet University, Saint-Etienne, France; French University Institute, Paris, France. 5. Department of Pathology, University Hospital of St-Etienne, Saint-Etienne, France. 6. Department of Ophthalmology, University Hospital of St-Etienne, Saint-Etienne, France.
Abstract
BACKGROUND: Handheld in vivo reflectance confocal microscopy (IVCM) is a new imaging method that allows noninvasive diagnosis of cutaneous tumors but to date it has not been used in the study of eyelid tumors. OBJECTIVE: We sought to evaluate the suitability of IVCM for eyelid margin tumors. METHODS: We prospectively evaluated the IVCM features of 47 eyelid margin lesions, clinically suspicious of malignancy; 35 of these were excised whereas the other 12, with no IVCM malignant features, were followed up for at least 1 year. Clinical, IVCM, and histologic diagnoses were compared. RESULTS: IVCM showed sensitivity and specificity of 100% and 69.2%, respectively, for malignancy (basal cell carcinoma, squamous cell carcinoma, and melanoma). The follow-up of the 12 nonexcised lesions did not show any clinical progression. LIMITATIONS: The lesions showing neither clinical nor IVCM features for malignancies were not biopsied in view of the potential functional and aesthetic consequences of eyelid margin surgery. CONCLUSION: Used with a handheld dermatology-specific microscope, IVCM can play a role in the noninvasive diagnosis of eyelid margin lesions. Further studies are needed to better define diagnostic criteria of eyelid tumors and improve the specificity of this technique.
BACKGROUND: Handheld in vivo reflectance confocal microscopy (IVCM) is a new imaging method that allows noninvasive diagnosis of cutaneous tumors but to date it has not been used in the study of eyelid tumors. OBJECTIVE: We sought to evaluate the suitability of IVCM for eyelid margin tumors. METHODS: We prospectively evaluated the IVCM features of 47 eyelid margin lesions, clinically suspicious of malignancy; 35 of these were excised whereas the other 12, with no IVCM malignant features, were followed up for at least 1 year. Clinical, IVCM, and histologic diagnoses were compared. RESULTS: IVCM showed sensitivity and specificity of 100% and 69.2%, respectively, for malignancy (basal cell carcinoma, squamous cell carcinoma, and melanoma). The follow-up of the 12 nonexcised lesions did not show any clinical progression. LIMITATIONS: The lesions showing neither clinical nor IVCM features for malignancies were not biopsied in view of the potential functional and aesthetic consequences of eyelid margin surgery. CONCLUSION: Used with a handheld dermatology-specific microscope, IVCM can play a role in the noninvasive diagnosis of eyelid margin lesions. Further studies are needed to better define diagnostic criteria of eyelid tumors and improve the specificity of this technique.
Authors: Mihaela Balu; Christopher B Zachary; Ronald M Harris; Tatiana B Krasieva; Karsten König; Bruce J Tromberg; Kristen M Kelly Journal: JAMA Dermatol Date: 2015-10 Impact factor: 10.282
Authors: Naiara Fraga Braghiroli; Samantha Sugerik; Luiz Antônio Rodrigues de Freitas; Margaret Oliviero; Harold Rabinovitz Journal: An Bras Dermatol Date: 2022-09-21 Impact factor: 2.113