Nadia Sawicka-Gutaj1, Aleksandra Klimowicz2, Jerzy Sowinski3, Robert Oleksa4, Maria Gryczynska5, Anna Wyszomirska6, Agata Czarnywojtek7, Marek Ruchala8. 1. Department of Endocrinology, Metabolism and Internal Medicine, Poznan University of Medical Sciences, 49, Przybyszewskiego Street, 60355 Poznan, Poland. Electronic address: nyha@tlen.pl. 2. Department of Endocrinology, Metabolism and Internal Medicine, Poznan University of Medical Sciences, 49, Przybyszewskiego Street, 60355 Poznan, Poland. Electronic address: oklim@wp.pl. 3. Department of Endocrinology, Metabolism and Internal Medicine, Poznan University of Medical Sciences, 49, Przybyszewskiego Street, 60355 Poznan, Poland. Electronic address: jsowin@ump.edu.pl. 4. Department of Endocrinology, Metabolism and Internal Medicine, Poznan University of Medical Sciences, 49, Przybyszewskiego Street, 60355 Poznan, Poland. Electronic address: roleksa@ump.edu.pl. 5. Department of Endocrinology, Metabolism and Internal Medicine, Poznan University of Medical Sciences, 49, Przybyszewskiego Street, 60355 Poznan, Poland. Electronic address: mgryczyn@ump.edu.pl. 6. Department of Endocrinology, Metabolism and Internal Medicine, Poznan University of Medical Sciences, 49, Przybyszewskiego Street, 60355 Poznan, Poland. Electronic address: andzin@amp.edu.pl. 7. Department of Endocrinology, Metabolism and Internal Medicine, Poznan University of Medical Sciences, 49, Przybyszewskiego Street, 60355 Poznan, Poland. Electronic address: agata.rat@wp.pl. 8. Department of Endocrinology, Metabolism and Internal Medicine, Poznan University of Medical Sciences, 49, Przybyszewskiego Street, 60355 Poznan, Poland. Electronic address: mruchala@ump.edu.pl.
Abstract
OBJECTIVES: The aim of the study was to assess the frequency of pyramidal lobe (PL) detected in iodine-131 (I-131) scans of thyroid bed in patients after thyroidectomy for differentiated thyroid cancer (DTC) and to investigate influence of PL on endogenous thyrotropin (TSH) stimulation as well as on the effects of the radio-iodine ablation in one-year follow-up. PATIENTS AND METHODS: This study was designed as a retrospective analysis of 302 radio-iodine neck scans of patients thyroidectomized due to DTC. The study population was selected from patients with PL detected in thyroid bed scintigraphy. Patients without PL were included to the control group. The study and the control groups did not differ in age, sex of patients, histological type and stage of the DTC. RESULTS: Pyramidal lobes were found in 30.5% of all patients. Patients in the study group underwent repeat surgery more often than controls without PL. Preablative TSH level in patients with PL was statistically lower than in the control group, in contrast to free thyroid hormones, which were higher in patients with PL. Preablative and postablative TSH-stimulated thyroglobulin (Tg) and antibodies against thyroglobulin (TgAbs) were measured in both groups, and comparison did not reveal differences. Moreover, for the per-patient analysis, sites of uptake in whole body scintigraphy performed 1 year after radio-iodine remnant ablation (RRA) did not differ between the study and the control groups. CONCLUSION: Pyramidal lobe decreases endogenous TSH stimulation without impact on radio-iodine therapy outcome in patients with DTC.
OBJECTIVES: The aim of the study was to assess the frequency of pyramidal lobe (PL) detected in iodine-131 (I-131) scans of thyroid bed in patients after thyroidectomy for differentiated thyroid cancer (DTC) and to investigate influence of PL on endogenous thyrotropin (TSH) stimulation as well as on the effects of the radio-iodine ablation in one-year follow-up. PATIENTS AND METHODS: This study was designed as a retrospective analysis of 302 radio-iodine neck scans of patients thyroidectomized due to DTC. The study population was selected from patients with PL detected in thyroid bed scintigraphy. Patients without PL were included to the control group. The study and the control groups did not differ in age, sex of patients, histological type and stage of the DTC. RESULTS: Pyramidal lobes were found in 30.5% of all patients. Patients in the study group underwent repeat surgery more often than controls without PL. Preablative TSH level in patients with PL was statistically lower than in the control group, in contrast to free thyroid hormones, which were higher in patients with PL. Preablative and postablative TSH-stimulated thyroglobulin (Tg) and antibodies against thyroglobulin (TgAbs) were measured in both groups, and comparison did not reveal differences. Moreover, for the per-patient analysis, sites of uptake in whole body scintigraphy performed 1 year after radio-iodine remnant ablation (RRA) did not differ between the study and the control groups. CONCLUSION:Pyramidal lobe decreases endogenous TSH stimulation without impact on radio-iodine therapy outcome in patients with DTC.
Keywords:
Cancer de la thyroïde; Cancer of thyroid; Glande thyroïde; Lobe pyramidal; Pyramidal lobe; Scintigraphie; Scintigraphy; Thyroid gland; Thyroidectomy; Thyroïdectomie
Authors: Nadia Sawicka-Gutaj; Joanna Waligórska-Stachura; Mirosław Andrusiewicz; Maciej Biczysko; Jerzy Sowiński; Jerzy Skrobisz; Marek Ruchała Journal: Tumour Biol Date: 2015-05-07