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Literature DB >> 24997686

Synthesis and biological evaluation of 2,3'-diindolylmethanes as agonists of aryl hydrocarbon receptor.

Gabrielle N Winston-McPherson¹, Dongxu Shu², Weiping Tang³.

Abstract

Recent studies suggest that arylhydrocarbon receptor (AhR) may be a target for a number of diseases. Natural product malassezin is a AhR agonist with an interesting 2,3'-diindolylmethane skeleton. We have prepared a series of analogues of natural product malassezin using our recently developed method and tested the activity of these analogues against AhR in a cell-based assay. We found that a methyl substituent at 1'-N can significantly increase the activity and the 2-formyl group is not critical for some diindolylmethanes.

Entities: CellLine Chemical Disease Gene Species

Keywords: Agonist; AhR; Diindolylmethane; Indole; Transcription factor

Mesh：

Substances：

Year: 2014 PMID： 24997686 PMCID： PMC4130779 DOI： 10.1016/j.bmcl.2014.06.009

Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823

30 in total

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Journal: Bioorg Med Chem Date: 2001-04 Impact factor: 3.641

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Journal: Chembiochem Date: 2005-05 Impact factor: 3.164

4. Platinum-catalyzed tandem indole annulation/arylation for the synthesis of diindolylmethanes and indolo[3,2-b]carbazoles.

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Journal: Org Lett Date: 2013-08-05 Impact factor: 6.005

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Journal: Mol Cell Biol Date: 1998-01 Impact factor: 4.272

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Journal: Chem Res Toxicol Date: 2007-12-13 Impact factor: 3.739

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