Literature DB >> 24996989

Superior vena cava syndrome caused by a malignant tumor: a retrospective single-center analysis of 124 cases.

Karin Hohloch1, Nick Bertram, Lorenz Trümper, Tim Beissbarth, Frank Griesinger.   

Abstract

PURPOSE: Superior vena cava syndrome (SVCS) results from compression of the superior vena cava. SVCS is an emergency requiring immediate diagnosis and treatment. We hypothesized that the outcome of patients (pts.) admitted during regular work hours may differ from that of pts. admitted on weekends.
METHODS: From 1992 to 2011, we analyzed all pts. admitted with SVCS due to a malignancy. Clinical outcome was analyzed, focusing on the work-up of pts. hospitalized on a weekend compared with those hospitalized during the week.
RESULTS: One hundred and twenty-four pts. with malignant causes of SVCS were analyzed. Causes were as follows: small cell lung cancer (SCLC) 28.2 %, non-small cell lung cancer 25 %, non-Hodgkin's lymphoma 25 %, metastasis of other malignant tumors 19.4 % and Hodgkin's disease 2.4 %. Sixty-five percent of pts. were admitted during the week and 35 % on a weekend. Sixty-one percent received chemotherapy, 24 % radiation, 4 % radiochemotherapy, 9 % palliative treatment and 2 % no treatment at all. No difference in choice of treatment between pts. admitted on a weekday versus weekend was seen. Response was as follows: 7 pts. complete remission, 20 pts. partial response, 38 pts. progressive disease, 3 pts. NC and 15 pts. died. Overall response rate was as follows: Hodgkin's disease 100 %, non-Hodgkin's lymphoma 29 %, SCLC 22.8 %, non-small cell lung cancer 9.6 % and metastatic cancer 16.6 %. Only 2 of the 34 pts. with relapsing carcinoma responded. None of the pts. died due to SVCS.
CONCLUSION: The outcome of pts. with SVCS is not dependent on the day of admission (weekend or weekday) but is related to underlying disease in the setting of a tertiary care center.

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Year:  2014        PMID: 24996989     DOI: 10.1007/s00432-014-1764-6

Source DB:  PubMed          Journal:  J Cancer Res Clin Oncol        ISSN: 0171-5216            Impact factor:   4.553


  15 in total

1.  History of aneurysms.

Authors:  W E STEHBENS
Journal:  Med Hist       Date:  1958-10       Impact factor: 1.419

2.  Treatment of malignant superior vena cava obstruction: metal stents or radiation therapy.

Authors:  A A Nicholson; D F Ettles; A Arnold; M Greenstone; J F Dyet
Journal:  J Vasc Interv Radiol       Date:  1997 Sep-Oct       Impact factor: 3.464

Review 3.  Clinical practice. Superior vena cava syndrome with malignant causes.

Authors:  Lynn D Wilson; Frank C Detterbeck; Joachim Yahalom
Journal:  N Engl J Med       Date:  2007-05-03       Impact factor: 91.245

4.  Radiotherapy in oncological emergencies--final results of a patterns of care study in Germany, Austria and Switzerland.

Authors:  Elmar Christian; Irinaeus A Adamietz; Normann Willich; Ulrich Schäfer; Oliver Micke
Journal:  Acta Oncol       Date:  2008       Impact factor: 4.089

Review 5.  Steroids, radiotherapy, chemotherapy and stents for superior vena caval obstruction in carcinoma of the bronchus.

Authors:  N P Rowell; F V Gleeson
Journal:  Cochrane Database Syst Rev       Date:  2001

Review 6.  Approach to the patient who presents with superior vena cava obstruction.

Authors:  A Abner
Journal:  Chest       Date:  1993-04       Impact factor: 9.410

Review 7.  A reassessment of the clinical implications of the superior vena caval syndrome.

Authors:  F R Ahmann
Journal:  J Clin Oncol       Date:  1984-08       Impact factor: 44.544

8.  The superior vena cava syndrome: clinical characteristics and evolving etiology.

Authors:  Todd W Rice; R Michael Rodriguez; Richard W Light
Journal:  Medicine (Baltimore)       Date:  2006-01       Impact factor: 1.889

9.  Clinical outcome of stenting in superior vena cava syndrome associated with malignant tumors. Comparison with conventional treatment.

Authors:  N Tanigawa; S Sawada; K Mishima; Y Okuda; K Mizukawa; N Ohmura; T Toita; K Ogawa; M Kobayashi; M Kobayashi
Journal:  Acta Radiol       Date:  1998-11       Impact factor: 1.990

Review 10.  Oncologic emergencies.

Authors:  Michael T McCurdy; Carl B Shanholtz
Journal:  Crit Care Med       Date:  2012-07       Impact factor: 7.598

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  2 in total

1.  Intracranial pressure monitoring during adult spinal deformity correction in a patient with critical venous occlusive disease and superior vena cava syndrome: A technical note.

Authors:  Alp Ozpinar; Jesse J Liu; Zachary J Tempel; Phillip A Choi; Robert A Hart; D Kojo Hamilton
Journal:  Surg Neurol Int       Date:  2016-04-20

Review 2.  Review of evolving etiologies, implications and treatment strategies for the superior vena cava syndrome.

Authors:  Christopher Straka; James Ying; Feng-Ming Kong; Christopher D Willey; Joseph Kaminski; D W Nathan Kim
Journal:  Springerplus       Date:  2016-02-29
  2 in total

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