Jill L Kaar1, Tessa Crume2, John T Brinton3, Kimberly J Bischoff4, Robert McDuffie5, Dana Dabelea2. 1. Department of Pediatrics, Colorado School of Medicine, University of Colorado Denver, Denver, CO. Electronic address: Jill.Kaar@ucdenver.edu. 2. Department of Epidemiology, Colorado School of Public Health, University of Colorado Denver, Denver, CO. 3. Department of Biostatistics and Informatics, Colorado School of Public Health, University of Colorado Denver, Denver, CO. 4. Institute for Health Research, Kaiser Permanente of Colorado, Denver, CO. 5. Department of Perinatology, Kaiser Permanente of Colorado, Denver, CO.
Abstract
OBJECTIVE: To determine whether adequate vs excessive gestational weight gain (GWG) attenuated the association between maternal obesity and offspring outcomes. STUDY DESIGN: Data from 313 mother-child pairs participating in the Exploring Perinatal Outcomes among Children study were used to test this hypothesis. Maternal prepregnancy body mass index (BMI) and weight measures throughout pregnancy were abstracted from electronic medical records. GWG was categorized according to the 2009 Institute of Medicine criteria as adequate or excessive. Offspring outcomes were obtained at a research visit (average age 10.4 years) and included BMI, waist circumference (WC), subcutaneous adipose tissue (SAT) and visceral adipose tissue, high-density lipoprotein cholesterol, and triglyceride levels. RESULTS: More overweight/obese mothers exceeded the Institute of Medicine GWG recommendations (68%) compared with normal-weight women (50%) (P < .01). Maternal prepregnancy BMI was associated with worse childhood outcomes, particularly among offspring of mothers with excessive GWG (increased BMI [20.34 vs 17.80 kg/m(2)], WC [69.23 vs 62.83 cm], SAT [149.30 vs 90.47 cm(2)], visceral adipose tissue [24.11 vs 17.55 cm(2)], and homeostatic model assessment [52.52 vs 36.69], all P < .001). The effect of maternal prepregnancy BMI on several childhood outcomes was attenuated for offspring of mothers with adequate vs excessive GWG (P < .05 for the interaction between maternal BMI and GWG status on childhood BMI, WC, SAT, and high-density lipoprotein cholesterol). CONCLUSION: Our findings lend support for pregnancy interventions aiming at controlling GWG to prevent childhood obesity.
OBJECTIVE: To determine whether adequate vs excessive gestational weight gain (GWG) attenuated the association between maternal obesity and offspring outcomes. STUDY DESIGN: Data from 313 mother-child pairs participating in the Exploring Perinatal Outcomes among Children study were used to test this hypothesis. Maternal prepregnancy body mass index (BMI) and weight measures throughout pregnancy were abstracted from electronic medical records. GWG was categorized according to the 2009 Institute of Medicine criteria as adequate or excessive. Offspring outcomes were obtained at a research visit (average age 10.4 years) and included BMI, waist circumference (WC), subcutaneous adipose tissue (SAT) and visceral adipose tissue, high-density lipoprotein cholesterol, and triglyceride levels. RESULTS: More overweight/obese mothers exceeded the Institute of Medicine GWG recommendations (68%) compared with normal-weight women (50%) (P < .01). Maternal prepregnancy BMI was associated with worse childhood outcomes, particularly among offspring of mothers with excessive GWG (increased BMI [20.34 vs 17.80 kg/m(2)], WC [69.23 vs 62.83 cm], SAT [149.30 vs 90.47 cm(2)], visceral adipose tissue [24.11 vs 17.55 cm(2)], and homeostatic model assessment [52.52 vs 36.69], all P < .001). The effect of maternal prepregnancy BMI on several childhood outcomes was attenuated for offspring of mothers with adequate vs excessive GWG (P < .05 for the interaction between maternal BMI and GWG status on childhood BMI, WC, SAT, and high-density lipoprotein cholesterol). CONCLUSION: Our findings lend support for pregnancy interventions aiming at controlling GWG to prevent childhood obesity.
Authors: R Ensenauer; A Chmitorz; C Riedel; N Fenske; H Hauner; U Nennstiel-Ratzel; R von Kries Journal: Int J Obes (Lond) Date: 2013-01-29 Impact factor: 5.095
Authors: Emily Oken; Sheryl L Rifas-Shiman; Alison E Field; A Lindsay Frazier; Matthew W Gillman Journal: Obstet Gynecol Date: 2008-11 Impact factor: 7.661
Authors: Stefanie N Hinkle; Andrea J Sharma; Deanne W Swan; Laura A Schieve; Usha Ramakrishnan; Aryeh D Stein Journal: J Nutr Date: 2012-09-05 Impact factor: 4.798
Authors: Abigail Fraser; Kate Tilling; Corrie Macdonald-Wallis; Naveed Sattar; Marie-Jo Brion; Li Benfield; Andy Ness; John Deanfield; Aroon Hingorani; Scott M Nelson; George Davey Smith; Debbie A Lawlor Journal: Circulation Date: 2010-06-01 Impact factor: 29.690
Authors: Annika L Bannon; Molly E Waring; Katherine Leung; Jessica V Masiero; Julie M Stone; Elizabeth C Scannell; Tiffany A Moore Simas Journal: Matern Child Health J Date: 2017-07
Authors: Elinor L Sullivan; Heidi M Rivera; Cadence A True; Juliana G Franco; Karalee Baquero; Tyler A Dean; Jeanette C Valleau; Diana L Takahashi; Tim Frazee; Genevieve Hanna; Melissa A Kirigiti; Leigh A Bauman; Kevin L Grove; Paul Kievit Journal: Am J Physiol Regul Integr Comp Physiol Date: 2017-04-12 Impact factor: 3.619
Authors: Natalie C Dosch; Elyssa F Guslits; Morgan B Weber; Shannon E Murray; Barbara Ha; Christopher L Coe; Anthony P Auger; Pamela J Kling Journal: J Pediatr Date: 2016-03-09 Impact factor: 4.406
Authors: Brandon H Hidaka; Jocelynn M Thodosoff; Elizabeth H Kerling; Holly R Hull; John Colombo; Susan E Carlson Journal: Am J Clin Nutr Date: 2018-01-01 Impact factor: 7.045