Literature DB >> 24996974

Changes in gene expression profile in two multidrug resistant cell lines derived from a same drug sensitive cell line.

Miguel Angelo Martins Moreira1, Carolina Bagni2, Marcos Barcelos de Pinho3, Thaís Messias Mac-Cormick2, Mateus dos Santos Mota3, Flávio Eduardo Pinto-Silva4, Nathalia Daflon-Yunes4, Vivian Mary Rumjanek4.   

Abstract

Resistance to chemotherapy is one of the most relevant aspects of treatment failure in cancer. Cell lines are used as models to study resistance. We analyzed the transcriptional profile of two multidrug resistant (MDR) cell lines (Lucena 1 and FEPS) derived from the same drug-sensitive cell K562. Microarray data identified 130 differentially expressed genes (DEG) between K562 vs. Lucena 1, 1932 between K562 vs. FEPS, and 1211 between Lucena 1 versus FEPS. The NOTCH pathway was affected in FEPS with overexpression of NOTCH2 and HEY1. The highly overexpressed gene in MDR cell lines was ABCB1, and both presented the ABCB1 promoter unmethylated.
Copyright © 2014 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  ABCB transporters; ABCB1; Cancer; MDR cell lines; Methylation; Multidrug resistance

Mesh：

Substances：

Year:  2014        PMID： 24996974     DOI： 10.1016/j.leukres.2014.06.001

Source DB:  PubMed          Journal:  Leuk Res        ISSN： 0145-2126            Impact factor:   3.156


  16 in total

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10.  Promoter methylation patterns of ABCB1, ABCC1 and ABCG2 in human cancer cell lines, multidrug-resistant cell models and tumor, tumor-adjacent and tumor-distant tissues from breast cancer patients.

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