Kim Dreyer1, Renée Out2, Peter G A Hompes3, Velja Mijatovic3. 1. Department of Reproductive Medicine, VU University Medical Center, Amsterdam, the Netherlands. Electronic address: k.dreyer@vumc.nl. 2. Department of Obstetrics and Gynecology, Spaarne Hospital, Hoofddorp, the Netherlands. 3. Department of Reproductive Medicine, VU University Medical Center, Amsterdam, the Netherlands.
Abstract
OBJECTIVE: To determine whether hysterosalpingo-foam sonography (HyFoSy) is a less painful first line tubal patency test than serial hysterosalpingography (HSG). DESIGN: A two-center, prospective, open-label, randomized, controlled trial. SETTING:University hospital and teaching hospital. PATIENT(S): 40 subfertile women, ages 18 to 41 years, with an indication for tubal patency testing as part of the fertility workup according to the Dutch Nederlandse Vereniging voor Obsteterie & Gynaecologie-guidelines. INTERVENTION(S): Tubal patency testing by HyFoSy versus serial HSG. MAIN OUTCOME MEASURE(S): Visual Analogue Scale (VAS) pain scores during tubal patency testing. RESULT(S): The median VAS score for pain perception during the HyFoSy procedure was 1.7 cm (interquartile range: 2.1) compared with 3.7 cm (interquartile range: 4.2) during HSG. The HyFoSy procedure also had a statistically significantly shorter procedure time compared with HSG, with a median of 5.0 minutes (interquartile range: 3.0) for HyFoSy versus 12.5 minutes (interquartile range: 16.0) for HSG. CONCLUSION(S): The HyFoSy procedure is a less painful and less time-consuming tubal patency test compared with HSG. CLINICAL TRIAL REGISTRATION NUMBER: Netherlands National Trial Register NTR3457.
RCT Entities:
OBJECTIVE: To determine whether hysterosalpingo-foam sonography (HyFoSy) is a less painful first line tubal patency test than serial hysterosalpingography (HSG). DESIGN: A two-center, prospective, open-label, randomized, controlled trial. SETTING: University hospital and teaching hospital. PATIENT(S): 40 subfertile women, ages 18 to 41 years, with an indication for tubal patency testing as part of the fertility workup according to the Dutch Nederlandse Vereniging voor Obsteterie & Gynaecologie-guidelines. INTERVENTION(S): Tubal patency testing by HyFoSy versus serial HSG. MAIN OUTCOME MEASURE(S): Visual Analogue Scale (VAS) pain scores during tubal patency testing. RESULT(S): The median VAS score for pain perception during the HyFoSy procedure was 1.7 cm (interquartile range: 2.1) compared with 3.7 cm (interquartile range: 4.2) during HSG. The HyFoSy procedure also had a statistically significantly shorter procedure time compared with HSG, with a median of 5.0 minutes (interquartile range: 3.0) for HyFoSy versus 12.5 minutes (interquartile range: 16.0) for HSG. CONCLUSION(S): The HyFoSy procedure is a less painful and less time-consuming tubal patency test compared with HSG. CLINICAL TRIAL REGISTRATION NUMBER: Netherlands National Trial Register NTR3457.
Authors: Nienke van Welie; Joukje van Rijswijk; Kim Dreyer; Machiel H A van Hooff; Jan Peter de Bruin; Harold R Verhoeve; Femke Mol; Wilhelmina M van Baal; Maaike A F Traas; Arno M van Peperstraten; Arentje P Manger; Judith Gianotten; Cornelia H de Koning; Aafke M H Koning; Neriman Bayram; David P van der Ham; Francisca P J M Vrouenraets; Michaela Kalafusova; Bob I G van de Laar; Jeroen Kaijser; Arjon F Lambeek; Wouter J Meijer; Frank J M Broekmans; Olivier Valkenburg; Lucy F van der Voet; Jeroen van Disseldorp; Marieke J Lambers; Rachel Tros; Cornelis B Lambalk; Jaap Stoker; Madelon van Wely; Patrick M M Bossuyt; Ben Willem J Mol; Velja Mijatovic Journal: Hum Reprod Date: 2022-05-03 Impact factor: 6.353
Authors: Joukje van Rijswijk; Nienke van Welie; Kim Dreyer; Machiel H A van Hooff; Jan Peter de Bruin; Harold R Verhoeve; Femke Mol; Kimiko A Kleiman-Broeze; Maaike A F Traas; Guido J J M Muijsers; Arentje P Manger; Judith Gianotten; Cornelia H de Koning; Aafke M H Koning; Neriman Bayram; David P van der Ham; Francisca P J M Vrouenraets; Michaela Kalafusova; Bob I G van de Laar; Jeroen Kaijser; Miriam F van Oostwaard; Wouter J Meijer; Frank J M Broekmans; Olivier Valkenburg; Lucy F van der Voet; Jeroen van Disseldorp; Marieke J Lambers; Henrike E Peters; Marit C I Lier; Cornelis B Lambalk; Madelon van Wely; Patrick M M Bossuyt; Jaap Stoker; Fulco van der Veen; Ben W J Mol; Velja Mijatovic Journal: BMC Womens Health Date: 2018-05-09 Impact factor: 2.809