Christopher J Hodcroft1, Melissa C Rossiter2, Ashesh N Buch3. 1. Department of Acute Medicine, Royal Glamorgan Hospital, Llantrisant, United Kingdom. 2. Department of Emergency Medicine, University Hospital of Wales, Cardiff, United Kingdom. 3. East Carolina Heart Institute, East Carolina University, Greenville, North Carolina.
Abstract
BACKGROUND: The use of cannabis is not usually regarded as a risk factor for acute coronary syndrome. However, several cases of myocardial infarction (MI) associated with cannabis use have been reported in the scientific literature. The etiology of this phenomenon is not known. OBJECTIVES: To present a case of cannabis-associated MI in which atherosclerotic coronary disease was excluded as a potential etiology by intravascular ultrasound examination, and briefly review the other possible mechanisms by which this effect may be mediated. CASE REPORT: We present the case of a previously healthy 21-year-old man who regularly smoked cannabis and presented to the Emergency Department with ST-elevation myocardial infarction after participating in a sport. He was also a cigarette smoker, but had no other conventional cardiovascular risk factors. At coronary angiography, a large amount of thrombus was found in the left anterior descending coronary artery. He recovered with medical treatment, and subsequent intravascular ultrasound examination showed no evidence of atherosclerosis at the site of the thrombus. CONCLUSION: Cannabis-associated MI is increasingly recognized. The etiology is unclear, but we believe this is the first report of the phenomenon where atherosclerotic plaque rupture has been excluded as the cause with a high degree of confidence.
BACKGROUND: The use of cannabis is not usually regarded as a risk factor for acute coronary syndrome. However, several cases of myocardial infarction (MI) associated with cannabis use have been reported in the scientific literature. The etiology of this phenomenon is not known. OBJECTIVES: To present a case of cannabis-associated MI in which atherosclerotic coronary disease was excluded as a potential etiology by intravascular ultrasound examination, and briefly review the other possible mechanisms by which this effect may be mediated. CASE REPORT: We present the case of a previously healthy 21-year-old man who regularly smoked cannabis and presented to the Emergency Department with ST-elevation myocardial infarction after participating in a sport. He was also a cigarette smoker, but had no other conventional cardiovascular risk factors. At coronary angiography, a large amount of thrombus was found in the left anterior descending coronary artery. He recovered with medical treatment, and subsequent intravascular ultrasound examination showed no evidence of atherosclerosis at the site of the thrombus. CONCLUSION: Cannabis-associated MI is increasingly recognized. The etiology is unclear, but we believe this is the first report of the phenomenon where atherosclerotic plaque rupture has been excluded as the cause with a high degree of confidence.
Authors: Alison M Dines; David M Wood; Miguel Galicia; Christopher M Yates; Fridtjof Heyerdahl; Knut Erik Hovda; Isabelle Giraudon; Roumen Sedefov; Paul I Dargan Journal: J Med Toxicol Date: 2015-12
Authors: Perry Wengrofsky; Ghassan Mubarak; Ahmed Shim; Pramod Theetha Kariyanna; Adam Buzidkowski; Jacob Schwartz; Samy I McFarlane Journal: Am J Med Case Rep Date: 2018